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AB219462

Recombinant Human Oligodendrocyte myelin glycoprotein (His tag C-Terminus)

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Recombinant Human Oligodendrocyte myelin glycoprotein (His tag C-Terminus) is a Human Full Length protein, in the 25 to 417 aa range, expressed in Baculovirus infected insect cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

대체 명칭 보기

OMGP, OMG, Oligodendrocyte-myelin glycoprotein

1 이미지
SDS-PAGE - Recombinant Human Oligodendrocyte myelin glycoprotein (His tag C-Terminus) (AB219462)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Oligodendrocyte myelin glycoprotein (His tag C-Terminus) (AB219462)

15% SDS-PAGE analysis of 3 μg ab219462.

Molecular Weight : 50-100 kDa (SDS–PAGE under reducing conditions).

주요 정보

Purity

>95% SDS-PAGE

Affinity purified

Endotoxin 레벨

< 1 EU/µg

발현 시스템

Baculovirus infected insect cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 7.4 Constituents: PBS, 10% Glycerol (glycerin, glycerine)

storage-buffer

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보완 제품

Reagents, Controls & Accessories

AB313996

Prestained Protein Ladder - Extra broad molecular weight (3 - 260 kDa)

SDS-PAGE - Prestained Protein Ladder - Extra broad molecular weight (3 - 260 kDa) (AB313996)

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Assay Kits

AB313914

Human Oligodendrocyte myelin glycoprotein ELISA Kit

Sandwich ELISA - Human Oligodendrocyte myelin glycoprotein ELISA Kit (AB313914)

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Primary Antibodies

AB224254

Anti-Oligodendrocyte myelin glycoprotein antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Oligodendrocyte myelin glycoprotein antibody (AB224254)

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Proteins & Peptides

AB288813

Recombinant Human CD80 protein (Active)

Premium Bioactive

Functional Studies - Recombinant Human CD80 protein (Active) (AB288813)

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Proteins & Peptides

AB276711

Recombinant Human KIR3DL3 protein (His tag)

SDS-PAGE - Recombinant Human KIR3DL3 protein (His tag) (AB276711)

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  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"ICPLQCICTERHRHVDCSGRNLSTLPSGLQENIIHLNLSYNHFTDLHNQLTQYTNLRTLDISNNRLESLPAHLPRSLWNMSAANNNIKLLDKSDTAYQWNLKYLDVSKNMLEKVVLIKNTLRSLEVLNLSSNKLWTVPTNMPSKLHIVDLSNNSLTQILPGTLINLTNLTHLYLHNNKFTFIPDQSFDQLFQLQEITLYNNRWSCDHKQNITYLLKWMMETKAHVIGTPCSTQISSLKEHNMYPTPSGFTSSLFTVSGMQTVDTINSLSVVTQPKVTKIPKQYRTKETTFGATLSKDTTFTSTDKAFVPYPEDTSTETINSHEAAAATLTIHLQDGMVTNTSLTSSTKSSPTPMTLSITSGMPNNFSEMPQQSTTLNLWREETTTNVKTPLPSVEHHHHHH","proteinLength":"Full Length","predictedMolecularWeight":"45.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":417,"aminoAcidStart":25,"nature":"Recombinant","expressionSystem":"Baculovirus infected insect cells","accessionNumber":"P23515","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Oligodendrocyte myelin glycoprotein (OMGP) also known as oligodendrocyte myelin marker has a molecular weight of approximately 50 kDa. It is a glycoprotein primarily found in the myelin of the central nervous system (CNS) notably in the white matter. OMGP appears as an element on the surface of oligodendrocytes and contributes significantly to the stability and function of the myelin sheath.
Biological function summary

OMGP plays an essential role in the CNS where it interacts with other structural components to maintain myelin integrity. OMGP is not a component of a larger complex but works closely with other myelin proteins such as myelin basic protein. It also inhibits neurite outgrowth helping regulate neural plasticity and potentially preventing improper nerve regeneration in mature central nervous systems.

Pathways

Research recognized OMGP as a contributor in the Nogo receptor (NgR) signaling pathway influencing the inhibition of axonal growth. Within this pathway OMGP associates with other proteins like Nogo-A and the receptor NgR1 regulating neuronal growth by binding to these proteins and suppressing neurite outgrowth. This interaction is important in maintaining the structural arrangement of the CNS and modulating its repair mechanisms.

OMGP has connections with multiple sclerosis (MS) and some neurodegenerative diseases. In MS changes in OMGP expression correlate with demyelination and faulty nerve function. Moreover OMGP interrelates with Nogo-A another protein present in damaged myelin which may influence disease progression by hindering nerve repair. ALS (Amyotrophic Lateral Sclerosis) research also considers OMGP's role in neurodegeneration suggesting a broader impact on CNS pathologies.
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일반 정보

기능

Cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system.

Post-translational modifications

O-glycosylated in its Ser/Thr-rich repeat domain.

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제품 프로토콜

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타겟 정보

Cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system.
See full target information OMG
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Product promise

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