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AB119460

Recombinant Human p18 INK4c/CDKN2C protein (His tag N-Terminus)

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Recombinant Human p18 INK4c/CDKN2C protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 168 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

대체 명칭 보기

CDKN6, CDKN2C, Cyclin-dependent kinase 4 inhibitor C, Cyclin-dependent kinase 6 inhibitor, p18-INK4c, p18-INK6

1 이미지
SDS-PAGE - Recombinant Human p18 INK4c/CDKN2C protein (His tag N-Terminus) (AB119460)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human p18 INK4c/CDKN2C protein (His tag N-Terminus) (AB119460)

15% SDS-PAGE showing ab119460 at approximately 20.7kDa (3μg).

주요 정보

Purity

>95% SDS-PAGE

ab119460 was purified using conventional chromatography techniques.

발현 시스템

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 1.17% Sodium chloride, 0.32% Tris HCl, 0.03% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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보완 제품

Reagents, Controls & Accessories

AB325995

Prestained Protein Ladder - Broad molecular weight (11-250 kDa, 5-color, 11 bands)

SDS-PAGE - Prestained Protein Ladder - Broad molecular weight (11-250 kDa, 5-color, 11 bands) (AB325995)

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  • 0
Primary Antibodies

AB192239

Anti-p18 INK4c/CDKN2C antibody [EPR15891]

RabMAb|Recombinant|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-p18 INK4c/CDKN2C antibody [EPR15891] (AB192239)

  • 0
  • 0
Primary Antibodies

AB109199

Anti-p21 antibody [EPR3993]

20ul selling size|KO Validated|RabMAb|Recombinant|Lab Essentials

Western blot - Anti-p21 antibody [EPR3993] (AB109199)

  • 4
  • 12
Primary Antibodies

AB32370

Anti-Bcl-XL antibody [E18]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Bcl-XL antibody [E18] (AB32370)

  • 5
  • 10
Primary Antibodies

AB131442

Anti-p53 antibody

Lab Essentials

Western blot - Anti-p53 antibody (AB131442)

  • 4
  • 7
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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제품 세부 정보

This product was previously labelled as p18 INK4c
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서열 정보

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMAEPWGNELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNLQ","proteinLength":"Full Length","predictedMolecularWeight":"20.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":168,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P42773","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

P18 INK4c also known as CDKN2C is a cyclin-dependent kinase inhibitor that plays an important role in cell cycle regulation. It is a member of the INK4 family and carries a molecular mass of approximately 18 kDa. This protein actively inhibits the activity of CDK4 and CDK6 key kinases that drive the transition from the G1 to S phase in the cell cycle. p18 INK4c is expressed in various tissues with notable expression in the adrenal gland kidney and the nervous system.
Biological function summary

P18 INK4c functions as a regulator by acting as a part of the complex that controls cell proliferation. It ensures that cells do not proceed through the G1/S checkpoint inappropriately maintaining proper cell cycle control. This protein serves as a brake in the cell cycle by binding to CDK4/6 thereby preventing their interaction with D-type cyclins and subsequent cell cycle progression.

Pathways

P18 INK4c is an important component of the retinoblastoma (Rb) pathway as well as the p16INK4a-pRB pathway. These pathways are important for negative regulation of the cell cycle. In these pathways p18 INK4c inhibits CDK4 and CDK6 which are kinases needed to phosphorylate the Rb protein a pivotal step for cell cycle progression. The regulation of these pathways plays a part in processes like cellular senescence and differentiation.

P18 INK4c is associated with various types of cancer including glioma and breast cancer. Alterations in the expression or function of p18 INK4c can lead to unchecked cell proliferation and tumorigenesis. It often interacts with proteins such as CDK4 and CDK6 in these contexts where dysregulation may contribute to the development and progression of the diseases. Understanding p18 INK4c's role could provide insights into potential therapeutic strategies for these cancers.
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일반 정보

기능

Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.

서열 유사성

Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.

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제품 프로토콜

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타겟 정보

Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.
See full target information CDKN2C
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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