Recombinant Human PAC-4 protein (His tag N-Terminus)

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PAC-4 also known as Protein Asephin C-4 is a protein involved mechanically in cellular processes within organisms. It has a known molecular mass of approximately 45 kDa. Researchers have noted its expression primarily in epithelial cells lymphocytes and other immune system-related tissues. This localization emphasizes its role within immune responses and cellular maintenance.

Biological function summary

PAC-4 plays a part in cell signaling and immune function regulation. It is associated with specific protein complexes that modulate signal transduction which affects immune activities. The interaction with these complexes suggests that PAC-4 controls the activation and suppression of various immune pathways important for maintaining the body's defense against pathogens. This role reinforces its importance in normal cellular activities.

Pathways

PAC-4 holds a significant role in signal transduction and the immune response pathways. It interacts particularly within the NF-kB signaling cascade impacting the transcription of DNA cytokine production and cell survival. PAC-4 interacts with proteins such as IκB and Bcl-3 which modulate these pathways either by promoting or inhibiting certain signaling events. These interactions underline its widespread influence within the immune system's regulatory framework.

Alterations in PAC-4 activity correlate with autoimmune diseases and certain types of cancer. In autoimmune conditions irregular PAC-4 functions can lead to excessive immune activation damaging healthy tissues. In cancer aberrant PAC-4 activity supports unchecked cell proliferation. It often connects with deregulated proteins like PI3K and JAK2 which play roles in these diseases illustrating its potential as a target for therapeutic intervention.