Recombinant Human PCMTD1 protein - BSA and Azide free (His tag N-Terminus)
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Recombinant Human PCMTD1 protein - BSA and Azide free (His tag N-Terminus) is a Human Fragment protein, in the 1 to 220 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE.
대체 명칭 보기
Protein-L-isoaspartate O-methyltransferase domain-containing protein 1, PCMTD1
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human PCMTD1 protein - BSA and Azide free (His tag N-Terminus) (AB174387)
SDS-PAGE analysis PCMTD1 using 3 μg of ab174387 on a 15% gel.
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This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The PCMTD1 enzyme prevents the accumulation of damaged proteins which could otherwise disrupt cellular functions. It forms part of a greater protein repair mechanism working alongside other correction processes to maintain protein integrity. Specifically PCMTD1 contributes to maintaining protein stability and functionality preventing erroneous protein folding that might disrupt normal cellular operations.
Pathways
Researchers place PCMTD1 within the protein repair and degradation pathways linking it to cellular proteostasis. It interacts with other enzymatic components involved in protein turnover such as the ubiquitin-proteasome system. This collaboration ensures damaged proteins are repaired or removed to uphold cell homeostasis. PCMTD1's role in these pathways is important for maintaining the balance between protein synthesis and degradation which is necessary for normal cellular functions.
일반 정보
기능
Substrate recognition component of an ECS (Elongin BC-CUL5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed : 35486881). Specifically binds to the methyltransferase cofactor S-adenosylmethionine (AdoMet) via the N-terminal AdoMet binding motif, but does not display methyltransferase activity (PubMed : 35486881). May provide an alternate maintenance pathway for modified proteins by acting as a damage-specific E3 ubiquitin ligase adaptor protein (PubMed : 35486881).
서열 유사성
Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
타겟 정보
Product promise
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