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AB125567

Recombinant human PDE1C/PDE1 protein (GST tag N-Terminus)

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Recombinant human PDE1C/PDE1 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 709 aa range, expressed in Baculovirus infected Sf9 cells, with >90%, suitable for SDS-PAGE, FuncS.
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Functional Studies - Recombinant human PDE1C/PDE1 protein (GST tag N-Terminus) (AB125567)
  • FuncS

Unknown

Functional Studies - Recombinant human PDE1C/PDE1 protein (GST tag N-Terminus) (AB125567)

The specific activity of ab125567 was determined to be 445 nmol/min/mg.

SDS-PAGE - Recombinant human PDE1C/PDE1 protein (GST tag N-Terminus) (AB125567)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant human PDE1C/PDE1 protein (GST tag N-Terminus) (AB125567)

SDS-PAGE analysis of ab125567.

주요 정보

Purity

>90% Densitometry

Purity was determined to be >90% by densitometry.

발현 시스템

Baculovirus infected Sf9 cells

Tags

GST tag N-Terminus

Applications

FuncS, SDS-PAGE

applications

Biologically active

Yes

Biological activity

The specific activity of ab125567 was determined to be 445 nmol/min/mg.

Accession

Q14123-1

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 7.5 Constituents: 25% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.79% Tris HCl, 0.31% Glutathione, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF

storage-buffer

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보완 제품

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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제품 세부 정보

This product was previously labelled as PDE1C
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서열 정보

[{"linker":null,"sequence":"","proteinLength":"Full Length","predictedMolecularWeight":"99 kDa","actualMolecularWeight":null,"aminoAcidEnd":709,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":null,"accessionNumber":"Q14123","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Dry Ice
적절한 단기 보관 조건
-80°C
적절한 장기 보관 조건
-80°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
True
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

PDE1C also known as phosphodiesterase 1C is an enzyme that mechanically regulates intracellular levels of cyclic nucleotides by hydrolyzing cAMP and cGMP. It has a mass of approximately 85 kDa. You can find PDE1C expression in various tissues including the brain heart and vascular smooth muscle. This expression pattern shows its importance in diverse physiological contexts where cAMP and cGMP act as second messengers.
Biological function summary

PDE1C functions as a calcium/calmodulin-dependent phosphodiesterase integrating signals where calcium levels fluctuate. It belongs to a larger family of phosphodiesterases that help modulate intracellular signaling pathways through cyclic nucleotide metabolism. This enzyme can operate independently or as part of complexes with other proteins which allows it to finely tune cellular response to external stimuli by adjusting cAMP and cGMP concentrations.

Pathways

PDE1C plays a significant role in key biological processes related to cyclic nucleotide signaling. It is particularly important in the regulation of the cardiovascular system by affecting vasodilation and cardiac contractility through pathways involving cAMP and cGMP. The enzyme is also involved in the smooth muscle relaxation pathway. PDE1C also interacts with calcium-dependent pathways to coordinate cellular responses that involve isoforms of proteins like PKG (cGMP-dependent protein kinase) and PKA (cAMP-dependent protein kinase).

Aberrant activity of PDE1C links to conditions such as cardiovascular diseases and certain cancers. Dysregulated expression of PDE1C can alter smooth muscle function and contribute to disorders like hypertension and cardiac hypertrophy. PDE1C also interacts with proteins like VEGF (vascular endothelial growth factor) in cancer biology where it can influence tumor growth and angiogenesis by modifying cellular proliferation through altered cyclic nucleotide signaling.
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일반 정보

기능

Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed : 29860631, PubMed : 8557689). Has a high affinity for both cAMP and cGMP (PubMed : 8557689). Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (Probable).

서열 유사성

Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.

Subcellular localisation

Lysosome

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제품 프로토콜

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타겟 정보

Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed : 29860631, PubMed : 8557689). Has a high affinity for both cAMP and cGMP (PubMed : 8557689). Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (Probable).
See full target information PDE1C

대체 명칭 보기

Cam-PDE 1C, Hcam3, PDE1C
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Product promise

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