Recombinant human PDE4D7 protein (Active) (GST tag N-Terminus)

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PDE4D7 also known as phosphodiesterase 4D7 is an isoform of the PDE4 family involved in the hydrolysis of cyclic adenosine monophosphate (cAMP). This protein has a mass of approximately 91 kDa. It plays an important role in modulating cellular responses by breaking down cAMP a second messenger critical for various signaling pathways. PDE4D7 exhibits expression in several tissues with high levels observed in the brain and prostate indicating its specialized functions in these areas.

Biological function summary

Phosphodiesterase 4D7 regulates intracellular cAMP concentrations affecting processes such as inflammation and memory formation. It does not typically form part of multi-protein complexes like some other PDE isoforms but it still interacts with other proteins to fulfill its regulatory functions. The maintenance of optimal cAMP levels by PDE4D7 is fundamental for neuronal signaling and other functions.

Pathways

Cyclic adenosine monophosphate degradation depends significantly on PDE4D7. This protein is involved in the cAMP signaling pathway closely linked to the regulation of inflammatory responses. PDE4D7 functions alongside other PDE4 isoforms like PDE4A and PDE4B contributing to fine-tuning the cAMP levels. Additionally it plays a role in the MAPK signaling pathway by influencing downstream effectors.

The dysregulation of PDE4D7 activity has implications in prostate cancer and depression. Changes in PDE4D7 expression levels associate with prostate cancer progression making it a potential biomarker in oncology. PDE4D7's involvement with PDE4B has been noted in depressive disorders where cAMP signaling imbalances occur. Both situations highlight PDE4D7's importance in disease mechanisms and its potential as a therapeutic target.