Recombinant Human Peroxiredoxin 1/PAG protein (His tag)
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Recombinant Human Peroxiredoxin 1/PAG protein (His tag) is a Human Full Length protein, in the 1 to 199 aa range, expressed in Yeast, with >85%, suitable for SDS-PAGE.
대체 명칭 보기
PAGA, PAGB, TDPX2, PRDX1, Peroxiredoxin-1, Natural killer cell-enhancing factor A, Proliferation-associated gene protein, Thioredoxin peroxidase 2, Thioredoxin-dependent peroxide reductase 2, Thioredoxin-dependent peroxiredoxin 1, NKEF-A, PAG
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human Peroxiredoxin 1/PAG protein (His tag) (AB241454)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) analysis with 5% enrichment gel and 15% separation gel of ab241454.
보완 제품
Proteins & Peptides
AB269099
Recombinant human UBCH6/UBE2E1 protein (Active) (His tag N-Terminus)
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추가 정보
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Peroxiredoxin 1 helps maintain cellular homeostasis by protecting cells from oxidative stress. It forms homodimers or interacts with other proteins to propagate cellular responses to changes in redox state. As an important member of the antioxidant defense mechanism it contributes to cellular signaling through modulation of hydrogen peroxide signaling pathways. The protein also plays a role in cell proliferation and apoptosis making it significant for cellular health and disease prevention.
Pathways
Peroxiredoxin 1 participates in critical processes such as the MAPK signaling and TGF-beta pathways. It interacts with MAPK-related proteins influencing cell survival and growth. Peroxiredoxin 1 indirectly modulates downstream signaling molecules that contribute to cellular responses. In these pathways the protein's antioxidant properties allow regulation of reactive oxygen species levels which directly affect cellular signaling cascades.
일반 정보
기능
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (PubMed : 9497357). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity).
서열 유사성
Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
Post-translational modifications
Phosphorylated on Thr-90 during the M-phase, which leads to a more than 80% decrease in enzymatic activity.. Acetylation increases reducing activity and resistance to superoxidation (PubMed:18606987). Deacetylated by HDAC6 which decreases reducing activity (PubMed:18606987).. The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) instead of its condensation to a disulfide bond. It can be reactivated by forming a transient disulfide bond with sulfiredoxin SRXN1, which reduces the cysteine sulfinic acid in an ATP- and Mg-dependent manner.
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