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AB160974

Recombinant Human PGCP protein (GST tag N-Terminus)

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Recombinant Human PGCP protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 472 aa range, expressed in Wheat germ, suitable for ELISA, WB.

대체 명칭 보기

LCH1, PGCP, CPQ, Carboxypeptidase Q, Lysosomal dipeptidase, Plasma glutamate carboxypeptidase

1 이미지
SDS-PAGE - Recombinant Human PGCP protein (GST tag N-Terminus) (AB160974)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human PGCP protein (GST tag N-Terminus) (AB160974)

ab160974 on a 12.5% SDS-PAGE stained with Coomassie Blue.

주요 정보

발현 시스템

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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보완 제품

Primary Antibodies

AB96159

Anti-PGCP antibody

Western blot - Anti-PGCP antibody (AB96159)

  • 0
  • 0
Primary Antibodies

AB201693

Anti-PIGK antibody [EPR17843]

20ul selling size|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-PIGK antibody [EPR17843] (AB201693)

  • 0
  • 0
Primary Antibodies

AB236630

Anti-CD9 antibody [EPR23105-121]

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD9 antibody [EPR23105-121] (AB236630)

  • 5
  • 4
Primary Antibodies

AB79559

Anti-CD81 antibody [M38]

BOND RX™ Validated|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD81 antibody [M38] (AB79559)

  • 4
  • 2
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MKFLIFAFFGGVHLLSLCSGKAICKNGISKRTFEEIKEEIASCGDVAKAIINLAVYGKAQNRSYERLALLVDTVGPRLSGSKNLEKAIQIMYQNLQQDGLEKVHLEPVRIPHWERGEESAVMLEPRIHKIAILGLGSSIGTPPEGITAEVLVVTSFDELQRRASEARGKIVVYNQPYINYSRTVQYRTQGAVEAAKVGALASLIRSVASFSIYSPHTGIQEYQDGVPKIPTACITVEDAEMMSRMASHGIKIVIQLKMGAKTYPDTDSFNTVAEITGSKYPEQVVLVSGHLDSWDVGQGAMDDGGGAFISWEALSLIKDLGLRPKRTLRLVLWTAEEQGGVGAFQYYQLHKVNISNYSLVMESDAGTFLPTGLQFTGSEKARAIMEEVMSLLQPLNITQVLSHGEGTDINFWIQAGVPGASLLDDLYKYFFFHHSHGDTMTVMDPKQMNVAAAVWAVVSYVVADMEEMLPRS","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":472,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9Y646","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Proprietary technique
배송 시 보관 조건
Dry Ice
적절한 단기 보관 조건
-80°C
적절한 장기 보관 조건
-80°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The protein PGCP also known as plasma glutamate carboxypeptidase functions mechanically by catalyzing the cleavage of C-terminal glutamate residues from its substrates. PGCP with a molecular mass approximately 55 kDa is highly expressed in the liver and kidney. Researchers have observed its expression in both human and mouse tissues which implies a conserved role across species. PGCP participates in processes that maintain proper levels of free glutamate an important amino acid in metabolic pathways.
Biological function summary

PGCP modulates the balance of circulating peptides by hydrolyzing carboxy-terminal glutamate. It does not operate as part of a larger protein complex but functions independently. By regulating peptides PGCP helps in processes like protein degradation and recycling. It also influences the bioavailability of certain hormones and metabolites thereby affecting metabolic and signal transduction pathways.

Pathways

PGCP actively partakes in the regulation of blood coagulation and metabolism of amino acids. It interacts with proteins like angiotensin II as it processes bioactive peptides involved in blood pressure regulation. Through these actions PGCP affects the renin-angiotensin system which plays a critical role in cardiovascular health. Additionally PGCP associates with amino acid metabolism pathways where its role in glutamate modulation supports cellular energy production and neurotransmitter synthesis.

PGCP's dysregulation connects it to hypertension and metabolic syndrome. Researchers link altered PGCP activity with imbalances in the renin-angiotensin system leading to increased blood pressure. Furthermore its interaction with proteins like bradykinin influences inflammatory responses and researchers hypothesize its involvement in metabolic syndrome due to its role in amino acid processing. Understanding PGCP's contributions aids in exploring therapeutic interventions for these conditions.
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일반 정보

기능

Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor.

서열 유사성

Belongs to the peptidase M28 family.

Post-translational modifications

N-glycosylated. The secreted form is modified by hybrid or complex type oligosaccharide chains (By similarity).

Subcellular localisation

Lysosome

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제품 프로토콜

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타겟 정보

Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor.
See full target information CPQ
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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