Recombinant Human PGRMC1 protein (GST tag N-Terminus)
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Recombinant Human PGRMC1 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 195 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.
대체 명칭 보기
HPR6.6, PGRMC, PGRMC1, Membrane-associated progesterone receptor component 1, mPR, Dap1, IZA
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human PGRMC1 protein (GST tag N-Terminus) (AB132523)
12.5% SDS-PAGE analysis of ab132523 stained with Coomassie Blue.
보완 제품
Reactivity 정보
서열 정보
특성 및 보관 정보
제형
Purification 테크닉
배송 시 보관 조건
적절한 단기 보관 조건
적절한 장기 보관 조건
분주 정보
보관 정보
추가 정보
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
PGRMC1 interacts with other proteins to influence cell cycle regulation and apoptosis. It is part of protein complexes that include Cytochrome P450 enzymes. These complexes aid in regulating steroidogenesis and drug metabolism. PGRMC1’s involvement in lipid homeostasis and membrane trafficking suggests its significant role in maintaining cell health and function.
Pathways
PGRMC1 integrates into the mevalonate pathway influencing cholesterol synthesis and steroidogenesis. It interacts with proteins such as CYP51A1 and is involved in the Wnt signaling pathway. These interactions affect cellular growth and differentiation linking PGRMC1 to pathway regulation and cellular stress responses.
일반 정보
기능
Component of a progesterone-binding protein complex (PubMed : 28396637). Binds progesterone (PubMed : 25675345). Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins (PubMed : 27599036). Forms a ternary complex with TMEM97 receptor and low density lipid receptor/LDLR, which increases LDLR-mediated LDL lipoprotein internalization (PubMed : 30443021).
서열 유사성
Belongs to the cytochrome b5 family. MAPR subfamily.
Post-translational modifications
O-glycosylated; contains chondroitin sulfate attached to Ser-54. Ser-54 is in the cytoplasmic domain but the glycosylated form was detected in urine, suggesting that the membrane-bound form is cleaved, allowing for production of a secreted form which is glycosylated.
타겟 정보
Product promise
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