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AB276686

Recombinant Human PGRP1B protein (His tag)

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Recombinant Human PGRP1B protein (His tag) is a Human Full Length protein, in the 1 to 373 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

대체 명칭 보기

PGRPIB, SBBI67, PGLYRP4, Peptidoglycan recognition protein 4, Peptidoglycan recognition protein I-beta, Peptidoglycan recognition protein intermediate beta, PGLYRPIbeta, PGRP-I-beta

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SDS-PAGE - Recombinant Human PGRP1B protein (His tag) (AB276686)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human PGRP1B protein (His tag) (AB276686)

SDS-PAGE analysis of ab276686

주요 정보

Purity

>95% SDS-PAGE

Endotoxin 레벨

< 1 EU/µg

발현 시스템

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 8.5 Constituents: 0.58% Sodium chloride, 0.24% Tris

storage-buffer

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보완 제품

Reagents, Controls & Accessories

AB116029

Prestained Protein Ladder - Extra broad molecular weight (5 - 245 kDa)

SDS-PAGE - Prestained Protein Ladder - Extra broad molecular weight (5 - 245 kDa) (AB116029)

  • 5
  • 1
Primary Antibodies

AB48012

Anti-PGRMC1 antibody

Western blot - Anti-PGRMC1 antibody (AB48012)

  • 4
  • 1
Proteins & Peptides

AB101774

Recombinant human ICK protein

Functional Studies - Recombinant human ICK protein (AB101774)

  • 0
  • 0
Proteins & Peptides

AB79251

Recombinant Human MGMT protein (His tag N-Terminus)

Western blot - Recombinant Human MGMT protein (His tag N-Terminus) (AB79251)

  • 0
  • 0
Proteins & Peptides

AB183256

Recombinant Human GNGT1 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human GNGT1 protein (His tag N-Terminus) (AB183256)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"sequence":"MLPWLLVFSALGIQAWGDSSWNKTQAKQVSEGLQYLFENISQLTEKGLPTDVSTTVSRKAWGAEAVGCSIQLTTPVNVLVIHHVPGLECHDQTVCSQRLRELQAHHVHNNSGCDVAYNFLVGDDGRVYEGVGWNIQGVHTQGYNNISLGFAFFGTKKGHSPSPAALSAMENLITYAVQKGHLSSSYVQPLLGKGENCLAPRQKTSLKKACPGVVPRSVWGARETHCPRMTLPAKYGIIIHTAGRTCNISDECRLLVRDIQSFYIDRLKSCDIGYNFLVGQDGAIYEGVGWNVQGSSTPGYDDIALGITFMGTFTGIPPNAAALEAAQDLIQCAMVKGYLTPNYLLVGHSDVARTLSPGQALYNIISTWPHFKH","proteinLength":"Full Length","predictedMolecularWeight":"40.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":373,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q96LB8","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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특성 및 보관 정보

제형
Lyophilized
배송 시 보관 조건
Ambient - Can Ship with Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

PGRP1B also known as Peptidoglycan Recognition Protein 1B plays an important role in the immune system. This protein has a molecular mass of approximately 20 kDa. It is expressed in several tissues including the liver and spleen. Mechanically PGRP1B recognizes peptidoglycan a component of bacterial cell walls. By binding to peptidoglycan it can participate in the degradation of bacterial components helping to detect and eliminate bacterial infections.
Biological function summary

Peptidoglycan Recognition Protein 1B serves as an important player in the innate immune response. It acts as solo rather than part of a larger protein complex. By identifying peptidoglycan PGRP1B can trigger immune responses that prevent bacterial growth. This activity supports the body’s first line of defense against pathogens helping to maintain cellular integrity by neutralizing potential threats.

Pathways

Peptidoglycan Recognition Protein 1B is involved in immune signaling and inflammatory pathways. In particular PGRP1B participates in pathways like the Toll-like receptor signaling which is key for activating immune responses. This protein interacts closely with other immune TLRs which share responsibility for detecting foreign molecules and activating downstream signals necessary for mounting effective immune responses.

An imbalance or dysfunction in Peptidoglycan Recognition Protein 1B can lead to problems such as autoimmune disorders or increased susceptibility to bacterial infections. Its activities are connected to inflammatory conditions where an abnormal response could trigger chronic inflammation. PGRP1B's failure to function properly leads to issues with related proteins like NOD1 and NOD2 which are also important in recognizing bacterial components and maintaining appropriate immune responses.
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일반 정보

기능

Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Also binds to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.

서열 유사성

Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

Post-translational modifications

N-glycosylated.

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제품 프로토콜

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타겟 정보

Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Also binds to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.
See full target information PGLYRP4
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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