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AB187487

Recombinant Human PIH1D2 protein (His tag N-Terminus)

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Recombinant Human PIH1D2 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 315 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.

대체 명칭 보기

PIH1 domain-containing protein 2, PIH1D2

1 이미지
SDS-PAGE - Recombinant Human PIH1D2 protein (His tag N-Terminus) (AB187487)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human PIH1D2 protein (His tag N-Terminus) (AB187487)

15% SDS-PAGE analysis of ab187487 (3 μg).

주요 정보

Purity

>85% SDS-PAGE

ab187487 was purified using conventional chromatography techniques.

발현 시스템

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 7.4 Constituents: PBS, 20% Glycerol (glycerin, glycerine), 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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보완 제품

Primary Antibodies

AB32503

Anti-Bax antibody [E63]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Bax antibody [E63] (AB32503)

  • 4
  • 12
Primary Antibodies

AB215903

Anti-Neurofilament antibody [NF421 + NFL/736]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Neurofilament antibody [NF421 + NFL/736] (AB215903)

  • 0
  • 0
Primary Antibodies

AB177487

Anti-NeuN antibody [EPR12763] - Neuronal Marker

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size|Advanced Validation

Immunohistochemistry (Frozen sections) - Anti-NeuN antibody [EPR12763] - Neuronal Marker (AB177487)

  • 5
  • 75
Primary Antibodies

AB278054

Anti-GFAP antibody [RM1003] - Astrocyte Marker

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GFAP antibody [RM1003] - Astrocyte Marker (AB278054)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMETSSKGLLTQVTQFWNLLDDLAQSDPEGYEKFIQQQLKEGKQLCAAPEPQLCLQTRILKPKEKILFINLCQWTRIPAPQSTTHPVPLTVGKPEDTTEISDAYTVIDVAYNPDVLHAAEKDQVKKNQLIQMAMKCIEEKFQFTLSHSYHITKFRIKGSIQRMKQNLMGIQTDSIDLREKMRRELTLGQIRSSTMSNPDHFPQLLLPKDQVSGKAVCLIEEISSTEIQVEMKMPAYELKIVHDHSEKPLKIELKVELPGINSVSLCDLSVSEDDLLIEVSEKYRLHLNLPKLIDTEMTTAKFIKEKSTLIITMPLV","proteinLength":"Full Length","predictedMolecularWeight":"38.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":315,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q8WWB5","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

PIH1D2 also known as Protein Interacting with HSP90 1D2 is a protein encoded by the PIH1D2 gene. It has a molecular mass of approximately 34 kDa. This protein is expressed in various tissues with notable expression in the testis and among cell lines derived from different human cancers. PIH1D2 is part of the R2TP complex which is involved in the assembly and stabilization of protein complexes within cells.
Biological function summary

PIH1D2 functions as a component of the R2TP complex which collaborates with the HSP90 chaperone machinery. This complex assists in the assembly and maintenance of complex protein structures including RNA polymerase complexes and small nucleolar ribonucleoproteins. PIH1D2 contributes to the stabilization of these protein structures facilitating proper cellular function and survival under stressful conditions.

Pathways

PIH1D2 plays roles in processes related to the assembly of RNA polymerase II and snoRNPs assembly pathways. It interacts with other proteins such as RPAP3 and HSP90. Through these interactions PIH1D2 aids in the complex formation and ensures the correct function of these biological pathways which are fundamental for transcriptional regulation and RNA processing.

Alterations in the function of PIH1D2 may link to cancer progression and neurological disorders. Specifically its involvement in protein assembly and RNA polymerase complexes indicates a connection to tumor growth and potentially neurodegenerative conditions. PIH1D2's interaction with the HSP90 protein chaperone highlights its importance in these disease contexts as HSP90 is recognized for its role in cancer cell proliferation and survival.
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일반 정보

서열 유사성

Belongs to the PIH1 family.

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제품 프로토콜

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타겟 정보

See full target information PIH1D2
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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