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AB162304

Recombinant Human PILRA protein (GST tag N-Terminus)

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Recombinant Human PILRA protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 226 aa range, expressed in Wheat germ, suitable for ELISA, WB.

대체 명칭 보기

Paired immunoglobulin-like type 2 receptor alpha, Cell surface receptor FDF03, Inhibitory receptor PILR-alpha, PILRA

1 이미지
SDS-PAGE - Recombinant Human PILRA protein (GST tag N-Terminus) (AB162304)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human PILRA protein (GST tag N-Terminus) (AB162304)

ab162304 on a 12.5% SDS-PAGE stained with Coomassie Blue.

주요 정보

발현 시스템

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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보완 제품

Reagents, Controls & Accessories

AB313995

Prestained Protein Ladder - Mid-range molecular weight (15 - 170 kDa)

SDS-PAGE - Prestained Protein Ladder - Mid-range molecular weight (15 - 170 kDa) (AB313995)

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Assay Kits

AB313923

Human PILRA ELISA Kit

Sandwich ELISA - Human PILRA ELISA Kit (AB313923)

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Proteins & Peptides

AB60842

Recombinant human PKC gamma protein (GST tag N-Terminus)

Western blot - Recombinant human PKC gamma protein (AB60842)

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Assay Kits

AB216944

Human Amyloid Precursor Protein ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Human Amyloid Precursor Protein ELISA Kit (AB216944)

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Biochemicals

AB120301

beta-Amyloid Peptide (1-42) (human)

Chemical Structure - beta-Amyloid Peptide (1-42) (human) (AB120301)

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MGRPLLLPLLPLLLPPAFLQPSGSTGSGPSYLYGVTQPKHLSASMGGSVEIPFSFYYPWELATAPDVRISWRRGHFHGQSFYSTRPPSIHKDYVNRLFLNWTEGQKSGFLRISNLQKQDQSVYFCRVELDTRSSGRQQWQSIEGTKLSITQGQQRTKATTPAREPFQNTEEPYENIRNEGQNTDPKLNPKLHLTQSTSQPPSPQEPPERDPVLCLKGLTNGQPSQD","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":226,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9UKJ1","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Proprietary technique
배송 시 보관 조건
Dry Ice
적절한 단기 보관 조건
-80°C
적절한 장기 보관 조건
-80°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

PILRA also known as Paired immunoglobulin-like type 2 receptor alpha is a protein with a mass of about 38 kDa. It belongs to the immunoglobulin superfamily and acts as an inhibitory receptor. PILRA is expressed mainly in human tissues such as monocytes macrophages and certain subsets of dendritic cells. It interacts with ligands through its extracellular domain and transmits inhibitory signals via its cytoplasmic tail that contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs).
Biological function summary

PILRA plays a significant role in the immune system regulation by inhibiting cellular activation processes. This regulation occurs through its participation in receptor-ligand interactions that modulate the immune response. It is not part of a complex but its pair PILRB acts as an activating receptor providing a balanced modulation of immune signaling. The balance between PILRA and PILRB affects how immune cells respond to various signals.

Pathways

PILRA is centrally involved in immune response pathways especially those controlling immune cell signaling. It interacts with proteins involved in immune system pathways such as LILRB1 which also mediates inhibitory signaling. PILRA functions in signaling pathways to regulate the activation and inhibition of immune responses maintaining immune system homeostasis.

PILRA associates with alterations in immune response mechanisms that can lead to autoimmune diseases and infections. Research links PILRA to diseases such as multiple sclerosis and certain viral infections. In these conditions PILRA's role in immune signaling modulation becomes important as it coordinates with proteins like PILRB to affect the immune system's response to different pathological conditions.
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일반 정보

기능

Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP.. (Microbial infection) Acts as an entry co-receptor for herpes simplex virus 1.

Post-translational modifications

According to PubMed:10660620, N- and O-glycosylated. According to PubMed:10903717, only N-glycosylated.. Phosphorylated on tyrosine residues.

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제품 프로토콜

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타겟 정보

Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP.. (Microbial infection) Acts as an entry co-receptor for herpes simplex virus 1.
See full target information PILRA
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Product promise

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