Recombinant Human PIMT protein (Tagged)

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The protein PIMT also known as Protein-L-isoaspartate (D-aspartate) O-methyltransferase mechanically functions to repair damaged proteins by methylation. It targets L-isoaspartyl residues in proteins converting them back to their normal aspartyl forms. This activity maintains protein integrity and function. PIMT has a molecular mass of approximately 25 kDa. It is expressed in various tissues with higher levels observed in the brain and liver suggesting its important role in these organs.

Biological function summary

PIMT plays an important role in protein repair and longevity by enzymatically correcting spontaneous deamidations that occur during the normal aging process. It is not part of a larger protein complex functioning independently. PIMT’s activity is fundamental in maintaining the structural stability of proteins therefore preventing cellular damage that can result from accumulating abnormal proteins.

Pathways

PIMT is involved in the protein repair pathway which is important for cellular homeostasis and viability. This pathway intersects with the post-translational modification pathway where PIMT stabilizes target proteins. It works alongside other repair-related proteins such as the protein L-isoaspartyl methyltransferase small domain (PIMT-SD) thereby ensuring minimal accumulation of damaged proteins and maintaining cellular function.

The impairment of PIMT's function has been linked to neurodegenerative diseases such as Alzheimer's disease due to the accumulation of damaged proteins in neural tissues. Additionally PIMT has connections to hepatic disorders given its significant expression in the liver. Deficiencies or mutations in PIMT can lead to an increased presence of pathological proteins exacerbating conditions associated with protein accumulation.