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AB101091

Recombinant Human PITPNB protein (His tag N-Terminus)

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Recombinant Human PITPNB protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 271 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

대체 명칭 보기

Phosphatidylinositol transfer protein beta isoform, PI-TP-beta, PtdIns transfer protein beta, PtdInsTP beta, PITPNB

1 이미지
SDS-PAGE - Recombinant Human PITPNB protein (His tag N-Terminus) (AB101091)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human PITPNB protein (His tag N-Terminus) (AB101091)

15% SDS-PAGE analysis of ab101091 (3μg)

주요 정보

Purity

>95% SDS-PAGE

ab101091 was purified using conventional chromatography techniques.

발현 시스템

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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보완 제품

Reagents, Controls & Accessories

AB325997

Prestained Protein Ladder - Extra broad molecular weight (3-250 kDa, 5-color)

SDS-PAGE - Prestained Protein Ladder - Extra broad molecular weight (3-250 kDa, 5-color) (AB325997)

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Proteins & Peptides

AB101666

Recombinant Human PITPN protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human PITPN protein (His tag N-Terminus) (AB101666)

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Primary Antibodies

AB127563

Anti-PITPNB antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PITPNB antibody (AB127563)

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Proteins & Peptides

AB99139

Recombinant Human NTF2 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human NTF2 protein (His tag N-Terminus) (AB99139)

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Proteins & Peptides

AB158453

Recombinant Human Filamin C protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human Filamin C protein (GST tag N-Terminus) (AB158453)

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMVLIKEFRVVLPCSVQEYQVGQLYSVAEASKNETGGGEGIEVLKNEPYEKDGEKGQYTHKIYHLKSKVPAFVRMIAPEGSLVFHEKAWNAYPYCRTIVTNEYMKDDFFIKIETWHKPDLGTLENVHGLDPNTWKTVEIVHIDIADRSQVEPADYKADEDPALFQSVKTKRGPLGPNWKKELANSPDCPQMCAYKLVTIKFKWWGLQSKVENFIQKQEKRIFTNFHRQLFCWIDKWIDLTMEDIRRMEDETQKELETMRKRGSVRGTSAADV","proteinLength":"Full Length","predictedMolecularWeight":"33.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":271,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P48739","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

PITPNB also known as phosphatidylinositol transfer protein beta isoform plays a role mechanically in lipid transfer between membranes. It weighs around 32 kDa. You can find this protein expressed in various tissues including the brain liver and lungs. PITPNB facilitates lipid metabolism and signaling by transferring phosphatidylinositol and phosphatidylcholine between membranes.
Biological function summary

PITPNB ensures the proper distribution of lipids within cells for membrane composition and signaling activities. It participates in maintaining the balance of lipid composition among cell membranes. PITPNB does not function alone; it often acts as part of lipid transfer complexes collaborating with other proteins to execute its function properly.

Pathways

PITPNB plays an active role in phosphoinositide signaling and membrane trafficking pathways. These pathways are critical for cell signaling and membrane dynamics. PI4K2A and PI4KA are proteins related to these pathways and interact with PITPNB highlighting its contribution to complex intracellular signaling processes.

Defects in PITPNB have been linked to metabolic disorders and neurodegenerative diseases such as Alzheimer's. PITPNB is connected to APOE a protein involved in lipid metabolism and associated with Alzheimer's disease progression. Understanding the role of PITPNB in these conditions opens possibilities for therapeutic strategies targeting lipid transfer processes.
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일반 정보

기능

Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (PubMed : 10531358, PubMed : 18636990, PubMed : 20332109). Also catalyzes the transfer of sphingomyelin (By similarity). Required for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum; phosphatidylinositol and phosphatidylcholine transfer activity is essential for this function (PubMed : 20332109).

서열 유사성

Belongs to the PtdIns transfer protein family. PI transfer class I subfamily.

Post-translational modifications

Constitutive phosphorylation of Ser-262 has no effect on phospholipid transfer activity but is required for Golgi targeting.

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제품 프로토콜

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타겟 정보

Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (PubMed : 10531358, PubMed : 18636990, PubMed : 20332109). Also catalyzes the transfer of sphingomyelin (By similarity). Required for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum; phosphatidylinositol and phosphatidylcholine transfer activity is essential for this function (PubMed : 20332109).
See full target information PITPNB
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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