AB271715
Recombinant human PLA2G7 protein (Active) (His tag C-Terminus)
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Recombinant human PLA2G7 protein (Active) (His tag C-Terminus) is a Human Full Length protein, in the 22 to 441 aa range, expressed in HEK 293 cells, with >91%, suitable for SDS-PAGE, FuncS.
2 이미지
- FuncS
Unknown
Functional Studies - Recombinant human PLA2G7 protein (Active) (His tag C-Terminus) (AB271715)
Specific activity of ab271715.
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant human PLA2G7 protein (Active) (His tag C-Terminus) (AB271715)
SDS-PAGE analysis of 5 μg ab271715.
보완 제품
Primary Antibodies
AB245045
Anti-PLA2G7 antibody [EPR20360-245] - BSA and Azide free (Detector)
RabMAb|Recombinant
![Sandwich ELISA - Anti-PLA2G7 antibody [EPR20360-245] - BSA and Azide free (Detector) (AB245045)](https://content.abcam.com/products/images/pla2g7-antibody-epr20360-245-bsa-and-azide-free-detector-ab245045--sandwich-elisa-img52761.jpg)
- 0
- 0
Reactivity 정보
{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
서열 정보
[{"linker":null,"sequence":"FDWQYINPVAHMKSSAWVNKIQVLMAAASFGQTKIPRGNGPYSVGCTDLMFDHTNKGTFLRLYYPSQDNDRLDTLWIPNKEYFWGLSKFLGTHWLMGNILRLLFGSMTTPANWNSPLRPGEKYPLVVFSHGLGAFRTLYSAIGIDLASHGFIVAAVEHRDRSASATYYFKDQSAAEIGDKSWLYLRTLKQEEETHIRNEQVRQRAKECSQALSLILDIDHGKPVKNALDLKFDMEQLKDSIDREKIAVIGHSFGGATVIQTLSEDQRFRCGIALDAWMFPLGDEVYSRIPQPLFFINSEYFQYPANIIKMKKCYSPDKERKMITIRGSVHQNFADFTFATGKIIGHMLKLKGDIDSNVAIDLSNKASLAFLQKHLGLHKDFDQWDCLIEGDDENLIPGTNINTTNQHIMLQNSSGIEKYN","proteinLength":"Full Length","predictedMolecularWeight":"49.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":441,"aminoAcidStart":22,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q13093","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
특성 및 보관 정보
제형
Liquid
배송 시 보관 조건
Dry Ice
적절한 단기 보관 조건
-80°C
적절한 장기 보관 조건
-80°C
보관 정보
Avoid freeze / thaw cycle
True
타겟 정보
Lipoprotein-associated calcium-independent phospholipase A2 involved in phospholipid catabolism during inflammatory and oxidative stress response (PubMed : 10066756, PubMed : 16371369, PubMed : 17090529, PubMed : 2040620, PubMed : 7700381, PubMed : 8624782). At the lipid-aqueous interface, hydrolyzes the ester bond of fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed : 10504265, PubMed : 2040620). Specifically targets phospholipids with a short-chain fatty acyl group at sn-2 position (PubMed : 2040620). Can hydrolyze phospholipids with long fatty acyl chains, only if they carry oxidized functional groups (PubMed : 2040620, PubMed : 8624782). Hydrolyzes and inactivates platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine), a potent pro-inflammatory signaling lipid that acts through PTAFR on various innate immune cells (PubMed : 10066756, PubMed : 10504265, PubMed : 11590221, PubMed : 16371369, PubMed : 18434304, PubMed : 7592717, PubMed : 7700381, PubMed : 8624782, PubMed : 8675689). Hydrolyzes oxidatively truncated phospholipids carrying an aldehyde group at omega position, preventing their accumulation in low-density lipoprotein (LDL) particles and uncontrolled pro-inflammatory effects (PubMed : 2040620, PubMed : 7700381). As part of high-density lipoprotein (HDL) particles, can hydrolyze phospholipids having long-chain fatty acyl hydroperoxides at sn-2 position and protect against potential accumulation of these oxylipins in the vascular wall (PubMed : 17090529). Catalyzes the release from membrane phospholipids of F2-isoprostanes, lipid biomarkers of cellular oxidative damage (PubMed : 16371369).
대체 명칭 보기
PAFAH, PLA2G7, Platelet-activating factor acetylhydrolase, PAF acetylhydrolase, 1-alkyl-2-acetylglycerophosphocholine esterase, 2-acetyl-1-alkylglycerophosphocholine esterase, Group-VIIA phospholipase A2, LDL-associated phospholipase A2, PAF 2-acylhydrolase, gVIIA-PLA2, LDL-PLA(2)
Product promise
저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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