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AB236342

Recombinant Human PNMA1 protein (Tagged)

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Recombinant Human PNMA1 protein (Tagged) is a Human Full Length protein, in the 1 to 353 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

대체 명칭 보기

MA1, PNMA1, Paraneoplastic antigen Ma1, 37 kDa neuronal protein, Neuron- and testis-specific protein 1

1 이미지
SDS-PAGE - Recombinant Human PNMA1 protein (Tagged) (AB236342)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human PNMA1 protein (Tagged) (AB236342)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel analysis of ab236342.

주요 정보

Purity

>85% SDS-PAGE

발현 시스템

Escherichia coli

Tags

10x His tag N-Terminus B2M-JD tag N-Terminus Myc tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

서열 정보

[{"linker":null,"sequence":"MAMTLLEDWCRGMDVNSQRALLVWGIPVNCDEAEIEETLQAAMPQVSYRMLGRMFWREENAKAALLELTGAVDYAAIPREMPGKGGVWKVLFKPPTSDAEFLERLHLFLAREGWTVQDVARVLGFQNPTPTPGPEMPAEMLNYILDNVIQPLVESIWYKRLTLFSGRDIPGPGEETFDPWLEHTNEVLEEWQVSDVEKRRRLMESLRGPAADVIRILKSNNPAITTAECLKALEQVFGSVESSRDAQIKFLNTYQNPGEKLSAYVIRLEPLLQKVVEKGAIDKDNVNQARLEQVIAGANHSGAIRRQLWLTGAGEGPAPNLFQLLVQIREEEAKEEEEEAEATLLQLGLEGHF","proteinLength":"Full Length","predictedMolecularWeight":"46.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":353,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q8ND90","tags":[{"tag":"10x His","terminus":"N-Terminus"},{"tag":"B2M-JD","terminus":"N-Terminus"},{"tag":"Myc","terminus":"C-Terminus"}]}]

특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
보관 정보
Avoid freeze / thaw cycle
False

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

PNMA1 known as Paraneoplastic Ma Antigen 1 is a protein involved in immunological processes. It has a molecular mass of approximately 40 kDa. This protein is expressed in various tissues including the brain and testis. It has notable relevance in certain neurological contexts associated with paraneoplastic syndromes. Studies have indicated that PNMA1 might play a role in cellular mechanisms involving immune surveillance or response due to its expression pattern and involvement in related pathways.
Biological function summary

PNMA1 interacts within cellular environments likely contributing to neuronal signaling or maintenance. It is suspected to be a part of a larger protein complex which may facilitate its role in modulating immune responses at the cellular level. As such it plays a role in the fine-tuning of immune system activities particularly in the context of tumors where altered expression patterns have been observed. Its presence in such pathway indicates a possible contribution to cellular defense mechanisms.

Pathways

PNMA1 is tied to the immune and neuronal communication paths within the human body. It integrates into the antigen processing and presentation pathway a critical function for recognizing and responding to tumor antigens. Its interactions with related proteins such as PNMA2 and PNMA3 suggest a broader set of functions in immune system regulation and tumor surveillance revealing the interconnected nature of these pathways in maintaining cellular homeostasis and defense.

PNMA1 has associations with paraneoplastic neurological syndromes and testicular cancer. These associations underline its importance in autoimmune responses elicited against nervous system antigens when expressed aberrantly in tumors. PNMA1 interacts with specific antibodies targeting neuronal tissue in paraneoplastic conditions linking it to disease manifestation. Its connection to PNMA2 and other neural-specific antigens suggests a broader spectrum of involvement in neurological immune disorders emphasizing the need for further investigation into its pathological significance.

일반 정보

서열 유사성

Belongs to the PNMA family.

Subcellular localisation

Nucleus

제품 프로토콜

Product promise

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