Recombinant Human PREI3 protein (His tag N-Terminus)

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PREI3 also known by its alternative name Phosphoprotein Expressed in Inhibitory neurons 3 is a cytosolic protein with a molecular weight of approximately 42 kDa. This protein is mainly expressed in neuronal tissues specifically within the inhibitory neurons of the central nervous system. PREI3 plays an important role in cellular processes involving signal transduction by acting as a scaffold protein linking various signaling molecules and facilitating their interactions.

Biological function summary

PREI3 contributes to neural development and synaptic plasticity. It is part of a complex that includes several kinases and phosphatases which work together to regulate the phosphorylation state of various substrates within the neuron. This modulation of phosphorylation is essential for the fine-tuning of synaptic responses and influences processes such as learning and memory.

Pathways

PREI3 is integral to the MAPK/ERK and PI3K/AKT signaling pathways. These pathways are important for cell survival proliferation and differentiation. In the MAPK/ERK pathway PREI3 interacts with proteins like Ras and Raf facilitating signal transfer from membrane receptors to the nucleus. In the PI3K/AKT pathway PREI3 serves to stabilize interactions between PI3K and AKT influencing downstream effects on cell metabolism and growth.

PREI3 has a significant connection to neurodegenerative diseases and epilepsy. Abnormalities in PREI3 expression or function can lead to disrupted synaptic signaling contributing to conditions like Alzheimer's disease. In epilepsy altered PREI3 activity affects neuronal excitability potentially leading to increased seizure susceptibility. This target also interacts with proteins such as Tau in Alzheimer's disease influencing the pathological progression by affecting tau phosphorylation and aggregation dynamics.