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AB271722

Recombinant Human PRMT10 protein (DDDDK N-Terminus + 6x His tag C-Terminus)

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Recombinant Human PRMT10 protein (DDDDK N-Terminus + 6x His tag C-Terminus) is a Human Full Length protein, in the 2 to 845 aa range, expressed in Baculovirus infected Sf9 cells, with 90%, suitable for SDS-PAGE.

대체 명칭 보기

PRMT10, PRMT9, Protein arginine N-methyltransferase 9, Protein arginine N-methyltransferase 10

1 이미지
SDS-PAGE - Recombinant Human PRMT10 protein (DDDDK N-Terminus + 6x His tag C-Terminus) (AB271722)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human PRMT10 protein (DDDDK N-Terminus + 6x His tag C-Terminus) (AB271722)

SDS-PAGE analysis of ab271722.

주요 정보

Purity

90% SDS-PAGE

Affinity purified.

발현 시스템

Baculovirus infected Sf9 cells

Tags

DDDDK tag N-Terminus 6x His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.64% Sodium chloride, 0.63% Tris HCl, 0.06% TCEP HCl, 0.04% Sorbitan monolaurate, ethoxylated, 0.02% Potassium chloride

storage-buffer

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보완 제품

Primary Antibodies

AB122374

Anti-PRMT10 antibody

Immunocytochemistry/ Immunofluorescence - Anti-PRMT10 antibody (AB122374)

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  • 0
Proteins & Peptides

AB89009

Recombinant Human RFK protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human RFK protein (His tag N-Terminus) (AB89009)

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  • 0
Primary Antibodies

AB151996

Anti-CYP2J2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CYP2J2 antibody (AB151996)

  • 4
  • 2
Assay Kits

AB150666

Copper Stain Kit

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Copper Stain Kit (AB150666)

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  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"SNSRPRSRRDAGGGAGAAGRDELVSRSLQSAEHCLGVQDFGTAYAHYLLVLSLAPELKHDVKETFQYTLFRWAEELDALSRIQDLLGCYEQALELFPDDEVICNSMGEHLFRMGFRDEAAGYFHKAVKLNPDFSDAKENFYRVANWLVERWHFIMLNDTKRNTIYNAAIQKAVCLGSKSVLDIGAGTGILSMFAKKAGAHSVYACELSKTMYELACDVVAANKMEAGIKLLHTKSLDIEIPKHIPERVSLVVTETVDAGLFGEGIVESLIHAWEHLLLQPKTKGESANCEKYGKVIPASAVIFGMAVECAEIRRHHRVGIKDIAGIHLPTNVKFQSPAYSSVDTEETIEPYTTEKMSRVPGGYLALTECFEIMTVDFNNLQELKSLATKKPDKIGIPVIKEGILDAIMVWFVLQLDDEHSLSTSPSEETCWEQAVYPVQDLADYWIKPGDHVMMEVSCQDCYLRIQSISVLGLECEMDVAKSFTQNKDLLSLGNEAELCSALANLQTSKPDAVEQTCILESTEIALLNNIPYHEGFKMAMSKVLSSLTPEKLYQTMDTHCQNEMSSGTGQSNTVQNILEPFYVLDVSEGFSVLPVIAGTLGQVKPYSSVEKDQHRIALDLISEANHFPKETLEFWLRHVEDESAMLQRPKSDKLWSIIILDVIEPSGLIQQEIMEKAAISRCLLQSGGKIFPQYVLMFGLLVESQTLLEENAVQGTERTLGLNIAPFINQFQVPIRVFLDLSSLPCIPLSKPVELLRLDLMTPYLNTSNREVKVYVCKSGRLTAIPFWYHMYLDEEIRLDTSSEASHWKQAAVVLDNPIQVEMGEELVLSIQHHKSNVSITVKQ","proteinLength":"Full Length","predictedMolecularWeight":"95 kDa","actualMolecularWeight":null,"aminoAcidEnd":845,"aminoAcidStart":2,"nature":"Recombinant","expressionSystem":"Baculovirus infected Sf9 cells","accessionNumber":"Q6P2P2","tags":[{"tag":"DDDDK","terminus":"N-Terminus"},{"tag":"6x His","terminus":"C-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification
배송 시 보관 조건
Dry Ice
적절한 단기 보관 조건
-80°C
적절한 장기 보관 조건
-80°C
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

PRMT10 also known as Protein Arginine Methyltransferase 10 participates in the methylation of arginine residues in target proteins. This enzyme functions mainly in cellular locations such as the nucleus and the cytoplasm. Weighing around 64 kDa PRMT10 modifies histones through methylation playing a critical role in transcriptional regulation and other chromatin-related processes. Expression of PRMT10 can be seen across many tissues with higher levels found in actively dividing cells due to its role in cell cycle regulation.
Biological function summary

PRMT10 affects chromatin structure and gene expression by methylating histones and other substrates. This protein often associates with complexes involved in transcriptional repression or activation. It targets histones like H3 and H4 influencing the recruitment of transcriptional machinery and chromatin remodelers. Through its enzymatic activity PRMT10 impacts processes like gene silencing DNA repair and signal transduction.

Pathways

The enzymatic activity of PRMT10 integrates with several cellular pathways. It prominently operates in the regulation of the Wnt signaling pathway and the cell cycle control pathway. PRMT10 works alongside related proteins such as β-catenin in Wnt signaling modulating gene expression patterns critical for cell growth and differentiation. Furthermore its interaction with cyclin-dependent kinases (CDKs) highlights its involvement in cell cycle checkpoints.

PRMT10 has been linked to cancer and neurodegenerative diseases. Aberrant expression and function of PRMT10 contribute to tumorigenesis by influencing oncogene and tumor suppressor gene expression. In cancer PRMT10 interacts with proteins like Myc enhancing its transcriptional activity which promotes cell proliferation. In neurodegenerative disorders altered PRMT10 activity affects neuronal gene expression highlighting its potential as a therapeutic target.
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일반 정보

기능

Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA). Specifically mediates the symmetrical dimethylation of SF3B2. Involved in the regulation of alternative splicing of pre-mRNA (PubMed : 25737013, PubMed : 25979344).

서열 유사성

Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.

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제품 프로토콜

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타겟 정보

Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA). Specifically mediates the symmetrical dimethylation of SF3B2. Involved in the regulation of alternative splicing of pre-mRNA (PubMed : 25737013, PubMed : 25979344).
See full target information PRMT9
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Product promise

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