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AB131853

Recombinant Human PRPF31 protein (GST tag N-Terminus)

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Recombinant Human PRPF31 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 499 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

대체 명칭 보기

PRP31, PRPF31, U4/U6 small nuclear ribonucleoprotein Prp31, Pre-mRNA-processing factor 31, Serologically defined breast cancer antigen NY-BR-99, U4/U6 snRNP 61 kDa protein, Protein 61K, hPrp31

1 이미지
SDS-PAGE - Recombinant Human PRPF31 protein (GST tag N-Terminus) (AB131853)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human PRPF31 protein (GST tag N-Terminus) (AB131853)

12.5% SDS-PAGE analysis of ab131853 stained with Coomassie Blue.

주요 정보

발현 시스템

Wheat germ

Tags

GST tag N-Terminus

Applications

SDS-PAGE, ELISA, WB

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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보완 제품

Reagents, Controls & Accessories

AB325995

Prestained Protein Ladder - Broad molecular weight (11-250 kDa, 5-color, 11 bands)

SDS-PAGE - Prestained Protein Ladder - Broad molecular weight (11-250 kDa, 5-color, 11 bands) (AB325995)

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Primary Antibodies

AB188577

Anti-PRPF31 antibody [EPR14587]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-PRPF31 antibody [EPR14587] (AB188577)

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Primary Antibodies

AB77285

Anti-ABCA4 antibody [3F4]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ABCA4 antibody [3F4] (AB77285)

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Proteins & Peptides

AB157866

Recombinant Human AP1B1 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human AP1B1 protein (GST tag N-Terminus) (AB157866)

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Primary Antibodies

AB156873

Anti-SF3A3 antibody [EPR10020]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SF3A3 antibody [EPR10020] (AB156873)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MSLADELLADLEEAAEEEEGGSYGEEEEEPAIEDVQEETQLDLSGDSVKTIAKLWDSKMFAEIMMKIEEYISKQAKASEVMGPVEAAPEYRVIVDANNLTVEIENELNIIHKFIRDKYSKRFPELESLVPNALDYIRTVKELGNSLDKCKNNENLQQILTNATIMVVSVTASTTQGQQLSEEELERLEEACDMALELNASKHRIYEYVESRMSFIAPNLSIIIGASTAAKIMGVAGGLTNLSKMPACNIMLLGAQRKTLSGFSSTSVLPHTGYIYHSDIVQSLPPDLRRKAARLVAAKCTLAARVDSFHESTEGKVGYELKDEIERKFDKWQEPPPVKQVKPLPAPLDGQRKKRGGRRYRKMKERLGLTEIRKQANRMSFGEIEEDAYQEDLGFSLGHLGKSGSGRVRQTQVNEATKARISKTLQRTLQKQSVVYGGKSTIRDRSSGTASSVAFTPLQGLEIVNPQAAEKKVAEANQKYFSSMAEFLKVKGEKSGLMST","proteinLength":"Full Length","predictedMolecularWeight":"81.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":499,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q8WWY3","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Proprietary technique
배송 시 보관 조건
Dry Ice
적절한 단기 보관 조건
-80°C
적절한 장기 보관 조건
-80°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

PRPF31 also known as pre-mRNA processing factor 31 is an important component of the spliceosomal complex. It weights approximately 56 kDa. This protein is expressed in various tissues with prominence in the retina. It plays a critical role in the assembly of the spliceosome by interacting with other splicing factors essential for processing pre-mRNA into mature mRNA.
Biological function summary

PRPF31 is involved in RNA splicing a process fundamental for gene expression. It forms part of the U4/U6-U5 snRNP complex which is responsible for catalyzing the splicing of pre-mRNA. PRPF31 facilitates the rearrangement of RNA and protein components within the spliceosome ensuring accurate splicing and removal of introns.

Pathways

The protein plays a role in the spliceosome pathway and genetic information processing. PRPF31 interacts with other splicing factors like PRPF6 and SNRNP200 within these pathways. Its activity is important for maintaining the fidelity and efficiency of spliceosome assembly and function linking gene regulation and expression to various cellular responses.

Mutations in PRPF31 lead to autosomal dominant retinitis pigmentosa a progressive retinal disorder. This condition connects PRPF31 to other retinal proteins like RP9. Its dysfunction disrupts normal splicing activities causing photoreceptor cell degeneration and vision loss. Understanding PRPF31's role provides insight into therapeutic targets for retinal diseases.
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일반 정보

기능

Involved in pre-mRNA splicing as component of the spliceosome (PubMed : 11867543, PubMed : 20118938, PubMed : 28781166). Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome (PubMed : 11867543).

서열 유사성

Belongs to the PRP31 family.

Post-translational modifications

Phosphorylated by PRP4K during spliceosome assembly.

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제품 프로토콜

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타겟 정보

Involved in pre-mRNA splicing as component of the spliceosome (PubMed : 11867543, PubMed : 20118938, PubMed : 28781166). Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome (PubMed : 11867543).
See full target information PRPF31
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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