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AB113161

Recombinant Human Rab24 protein (His tag N-Terminus)

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Recombinant Human Rab24 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 227 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

대체 명칭 보기

Ras-related protein Rab-24, RAB24

1 이미지
SDS-PAGE - Recombinant Human Rab24 protein (His tag N-Terminus) (AB113161)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Rab24 protein (His tag N-Terminus) (AB113161)

ab113161 at 3 μg analysed by 15% SDS PAGE.

주요 정보

Purity

>90% SDS-PAGE

ab113161 was purified by using conventional chromatography techniques

발현 시스템

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 8 Constituents: 30% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl, 0.03% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.03% EDTA

storage-buffer

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보완 제품

Reagents, Controls & Accessories

AB116027

Prestained Protein Ladder - Mid-range molecular weight (10 - 180 kDa)

SDS-PAGE - Prestained Protein Ladder - Mid-range molecular weight (10 - 180 kDa) (AB116027)

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  • 2
Primary Antibodies

AB154824

Anti-Rab24 antibody [EPR9131]

RabMAb|Recombinant

Western blot - Anti-Rab24 antibody [EPR9131] (AB154824)

  • 0
  • 0
Reagents, Controls & Accessories

AB7486

Normal Mouse Serum (sterile)

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  • 0
Assay Kits

AB204718

Succinate Assay Kit (Colorimetric)

Functional Studies - Succinate Assay Kit (Colorimetric) (AB204718)

  • 5
  • 1
Assay Kits

AB273333

Asparagine Assay Kit (Fluorometric)

Functional Studies - Asparagine Assay Kit (Fluorometric) (AB273333)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMGSHMSGQRVDVKVVMLGKEYVGKTSLVERYVHDRFLVGPYQNTIGAAFVAKVMSVGDRTVTLGIWDTAGSERYEAMSRIYYRGAKAAIVCYDLTDSSSFERAKFWVKELRSLEEGCQIYLCGTKSDLLEEDRRRRRVDFHDVQDYADNIKAQLFETSSKTGQSVDELFQKVAEDYVSVAAFQVMTEDKGVDLGQKPNPYFYSCCHH","proteinLength":"Full Length","predictedMolecularWeight":"25.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":227,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q969Q5","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Rab24 also known as Ras-related protein Rab-24 is a member of the Rab GTPase family. It participates in intracellular vesicle trafficking by functioning as a molecular switch that cycles between inactive GDP-bound and active GTP-bound states. Rab24 has a molecular weight of approximately 23 kDa. This protein is expressed in various tissues including the brain and testis suggesting it plays diverse roles in these areas.
Biological function summary

The Rab24 protein is essential in autophagy a cellular process that degrades and recycles components. It is known to participate in the formation of autophagic vacuoles a part of the greater autophagy pathway. Although not primarily part of a larger complex its interaction with other proteins supports the cell's homeostatic balance. Rab24 is less understood compared to other Rab proteins making it the focus of research for its unique properties.

Pathways

Involvement in autophagy and endocytic trafficking is established for Rab24. It plays a role in the regulation of intracellular membrane trafficking essential for cellular maintenance and nutrient supply. Rab24 associates with proteins such as LC3 during autophagic vacuole formation. These interactions position Rab24 as a significant player in pathways that maintain cellular health and response to stress.

Dysfunctional Rab24 activity has connections to neurodegenerative diseases and cancer. Abnormalities in autophagy linked to Rab24 mutations or dysregulation can contribute to conditions like Alzheimer's disease. Rab24's interplay with proteins like LC3 highlights its importance as these connections underline the potential for therapeutic targeting to address these disorders' underlying mechanisms.
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일반 정보

기능

May be involved in autophagy-related processes.

서열 유사성

Belongs to the small GTPase superfamily. Rab family.

Post-translational modifications

Isoprenylation is inefficient compared to other Rab family members.

Subcellular localisation

Cytoskeleton

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제품 프로토콜

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타겟 정보

May be involved in autophagy-related processes.
See full target information Ras-related protein Rab-24
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Product promise

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