Recombinant human RANKL protein (Active)
- Bioactive
- 각 태그의 뜻
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Recombinant human RANKL protein (Active) is a Human Fragment protein, in the 143 to 317 aa range, expressed in Escherichia coli, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, FuncS.
대체 명칭 보기
CD254, OPGL, RANKL, TRANCE, TNFSF11, Tumor necrosis factor ligand superfamily member 11, Osteoclast differentiation factor, Osteoprotegerin ligand, Receptor activator of nuclear factor kappa-B ligand, TNF-related activation-induced cytokine, ODF
- FuncS
Unknown
Functional Studies - Recombinant human RANKL protein (Active) (AB269158)
Biological activity graph of ab269158
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant human RANKL protein (Active) (AB269158)
SDS-PAGE analysis of ab269158 at 1ug/lane under (-) non-reducing and (+) reducing conditions. 4-20% Tris glycine gel. Stained with coomassie blue.
보완 제품
![Immunocytochemistry/ Immunofluorescence - Anti-RANKL antibody [12A668] - BSA and Azide free (AB45039)](https://content.abcam.com/products/images/rankl-antibody-12a668-bsa-and-azide-free-ab45039--immunocytochemistry-immunofluorescence-img16175.jpg)
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일반 정보
기능
Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy (PubMed : 22664871). Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation (By similarity).
서열 유사성
Belongs to the tumor necrosis factor family.
Post-translational modifications
The soluble form of isoform 1 derives from the membrane form by proteolytic processing (By similarity). The cleavage may be catalyzed by ADAM17.
타겟 정보
Product promise
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