Recombinant Human RhoGDI protein (GST tag N-Terminus)
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Recombinant Human RhoGDI protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 204 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.
대체 명칭 보기
GDIA1, ARHGDIA, Rho GDP-dissociation inhibitor 1, Rho GDI 1, Rho-GDI alpha
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human RhoGDI protein (GST tag N-Terminus) (AB132108)
12.5% SDS-PAGE analysis of ab132108, stained with Coomassie Blue.
보완 제품
Reactivity 정보
서열 정보
특성 및 보관 정보
제형
Purification 테크닉
배송 시 보관 조건
적절한 단기 보관 조건
적절한 장기 보관 조건
분주 정보
보관 정보
추가 정보
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
RhoGDI modulates the activity of Rho family GTPases—a group responsible for organizing the actin cytoskeleton which determines cell shape polarity and movement. It does not operate alone; rather it is part of a complex with membrane-bound and cytosolic proteins offering a shuttle service to balance GTPases between cellular locations. By doing so RhoGDI influences processes like cell migration and the cell cycle integral to maintaining proper cellular architecture.
Pathways
Scientists recognize RhoGDI’s participation in key signaling pathways particularly the Rho GTPase cycle and actin cytoskeleton organization. It interacts with proteins like ROCK and PAK within these pathways to achieve precise control of cytoskeletal dynamics. RhoGDI coordinates with these proteins to play a central role in cellular responses to external stimuli impacting processes like wound healing and cellular development.
일반 정보
기능
Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1.
서열 유사성
Belongs to the Rho GDI family.
타겟 정보
Product promise
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