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AB156337

Recombinant Human RPL23A protein (His tag N-Terminus)

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Recombinant Human RPL23A protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 156 aa range, expressed in Escherichia coli, with >80%, suitable for SDS-PAGE, Mass Spec.

대체 명칭 보기

Large ribosomal subunit protein uL23, 60S ribosomal protein L23a, RPL23A

1 이미지
SDS-PAGE - Recombinant Human RPL23A protein (His tag N-Terminus) (AB156337)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human RPL23A protein (His tag N-Terminus) (AB156337)

15% SDS-PAGE analysis of ab156337 (3µg).

주요 정보

Purity

>80% SDS-PAGE

ab156337 is purified using conventional chromatography techniques.

발현 시스템

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 8 Preservative: 1.7% Imidazole Constituents: 50% Glycerol (glycerin, glycerine), 1.17% Sodium chloride, 0.32% Tris HCl, 0.03% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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보완 제품

Reagents, Controls & Accessories

AB325995

Prestained Protein Ladder - Broad molecular weight (11-250 kDa, 5-color, 11 bands)

SDS-PAGE - Prestained Protein Ladder - Broad molecular weight (11-250 kDa, 5-color, 11 bands) (AB325995)

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Primary Antibodies

AB157110

Anti-RPL23A antibody

Immunoprecipitation - Anti-RPL23A antibody (AB157110)

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Proteins & Peptides

AB152374

Recombinant Human FANCA/FAA protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human FANCA/FAA protein (GST tag N-Terminus) (AB152374)

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Proteins & Peptides

AB268550

Recombinant Human FANCL protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human FANCL protein (Tagged) (AB268550)

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Proteins & Peptides

AB276516

Recombinant Human AFM protein (His tag)

SDS-PAGE - Recombinant Human AFM protein (His tag) (AB276516)

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMAPKAKKEAPAPPKAEAKAKALKAKKAVLKGVHSHKKKKIRTSPTFRRPKTLRLRRQPKYPRKSAPRRNKLDHYAIIKFPLTTESAMKKIEDNNTLVFIVDVKANKHQIKQAVKKLYDIDVAKVNTLIRPDGEKKAYVRLAPDYDALDVANKIGII","proteinLength":"Full Length","predictedMolecularWeight":"20.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":156,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P62750","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

RPL23A also known as Ribosomal Protein L23a is a component of the 60S subunit in the ribosome which is responsible for protein synthesis. It has a molecular mass of approximately 15 kDa. RPL23A is expressed in various tissues but shows significant expression levels in the liver and pancreas. The protein plays a mechanical role by ensuring structural stability and proper functioning of the ribosome during translation.
Biological function summary

RPL23A participates in the assembly and function of the ribosomal complex critical for translation. Within this complex RPL23A contributes to the coordination of protein synthesis by helping to align mRNA and tRNA correctly. This alignment is essential for the catalysis of peptide bond formation between amino acids allowing for the accurate synthesis of proteins.

Pathways

RPL23A is integral to the mTOR signaling pathway and the p53 signaling pathway. The mTOR pathway regulates cell growth proliferation and survival in response to nutrients growth factors and cellular energy levels with RPL23A interacting with proteins like TSC1 and TSC2. In the p53 signaling pathway RPL23A can influence cellular responses to DNA damage and stress by interacting with proteins such as MDM2.

RPL23A is implicated in cancer and Diamond-Blackfan anemia. In cancer the dysregulation of RPL23A can affect ribosome biogenesis and cell proliferation often seen in conjunction with increased levels of proteins like c-Myc. In Diamond-Blackfan anemia mutations or malfunctions in RPL23A lead to defective ribosomal function impacting erythroid progenitor cells and causing anemia with links to other ribosomal proteins such as RPS19.
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일반 정보

기능

Component of the large ribosomal subunit (PubMed : 23636399, PubMed : 32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed : 23636399, PubMed : 32669547). Binds a specific region on the 26S rRNA (PubMed : 23636399, PubMed : 32669547). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (PubMed : 26203195).

서열 유사성

Belongs to the universal ribosomal protein uL23 family.

Post-translational modifications

N-terminus is methylated by METTL11A/NTM1.. Citrullinated by PADI4.

Subcellular localisation

Nucleus

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제품 프로토콜

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타겟 정보

Component of the large ribosomal subunit (PubMed : 23636399, PubMed : 32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed : 23636399, PubMed : 32669547). Binds a specific region on the 26S rRNA (PubMed : 23636399, PubMed : 32669547). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (PubMed : 26203195).
See full target information 60S ribosomal protein L23a
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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