Recombinant Human RPS6KL1 protein (GST tag N-Terminus)

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RPS6KL1 also known as ribosomal protein S6 kinase-like 1 functions as a serine/threonine kinase. This protein has a mass of approximately 106 kDa. RPS6KL1 plays a role in cellular signaling and exists in various tissues with higher expression in the brain and testis. It modulates cell proliferation by phosphorylating downstream targets influencing cell growth and survival.

Biological function summary

RPS6KL1 regulates protein synthesis and cell cycle progression. It acts as part of a signaling complex involving ribosomal protein S6 impacting translation initiation and elongation. This activity places RPS6KL1 in critical processes of cellular metabolism and growth ensuring cells respond to external stimuli efficiently.

Pathways

RPS6KL1 operates within the mTOR signaling pathway which controls cell growth and metabolism in response to nutrients and growth factors. It also interacts with the PI3K/AKT pathway. Through these pathways RPS6KL1 connects with proteins like mTOR and AKT enabling coordination of cellular responses to maintain homeostasis and promote cell viability.

RPS6KL1 has associations with cancer and neurodegenerative diseases reflecting its role in cell proliferation and survival. It interacts with proteins such as mTOR in cancer where dysregulation of its pathways can lead to uncontrolled cell growth. In neurodegenerative diseases alterations in RPS6KL1 expression or function may disrupt neuronal survival linking it with proteins involved in neural signaling and cell death.