Recombinant Human S100A16 protein (His tag N-Terminus)

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S100A16 also known as S100 calcium-binding protein A16 belongs to the S100 protein family. With a molecular mass of approximately 10.7 kDa S100A16 plays a role in the regulation of calcium homeostasis and cell differentiation. It is expressed in various tissues including the brain heart and adipose tissue. Like other S100 proteins S100A16 possesses two EF-hand motifs which facilitate its ability to bind to calcium ions influencing its structural conformation and function.

Biological function summary

S100A16 is involved in cellular processes such as proliferation differentiation and migration. It participates in the modulation of cytoskeletal dynamics and cell cycle regulation. S100A16 often integrates into multiprotein complexes where it interacts with target proteins to exert its biological effects. Studies show that S100A16 may also contribute to epithelial-mesenchymal transition (EMT) an important event in development and cancer progression.

Pathways

S100A16 functions in signaling pathways linked to calcium-dependent processes. In the MAPK signaling pathway it interacts with proteins like ERK1/2 to regulate cell proliferation and survival. Furthermore S100A16 is also associated with the TGF-beta pathway where its role in EMT becomes significant and involves interactions with TGF-beta-related factors. These pathways underline the importance of S100A16 in cellular homeostasis and developmental processes.

S100A16 is implicated in cancer and metabolic disorders. Its overexpression has been observed in several types of cancer including breast and colorectal cancer where it might contribute to tumor progression and metastasis. S100A16 also interacts with proteins like MMPs which are involved in tissue remodeling and invasion. Additionally S100A16 plays a part in metabolic diseases potentially through its role in adipocyte differentiation and lipid metabolism highlighting its multifaceted contribution to human health and disease.