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AB181918

Recombinant Human SAMSN1 protein (His tag N-Terminus)

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Recombinant Human SAMSN1 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 373 aa range, expressed in Escherichia coli, with >80%, suitable for SDS-PAGE, Mass Spec.

대체 명칭 보기

HACS1, SAMSN1, SAM domain-containing protein SAMSN-1, Hematopoietic adaptor containing SH3 and SAM domains 1, Nash1, SH3-SAM adaptor protein

1 이미지
SDS-PAGE - Recombinant Human SAMSN1 protein (His tag N-Terminus) (AB181918)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human SAMSN1 protein (His tag N-Terminus) (AB181918)

15% SDS-PAGE analysis of ab181918 (3μg).

주요 정보

Purity

>80% SDS-PAGE

ab181918 was purified by using conventional chromatography.

발현 시스템

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 8 Constituents: 30% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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보완 제품

Proteins & Peptides

AB167927

Recombinant human PRMT1 protein (GST tag N-Terminus)

Functional Studies - Recombinant human PRMT1 protein (AB167927)

  • 0
  • 0
Primary Antibodies

AB236402

Anti-OBFC2A antibody [OTI6B10]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OBFC2A antibody [OTI6B10] (AB236402)

  • 0
  • 0
Primary Antibodies

AB3375

Anti-MRP3 antibody [M3II-9]

Functional Studies - Anti-MRP3 antibody [M3II-9] (AB3375)

  • 4
  • 3
Primary Antibodies

AB190892

Anti-PRMT1 antibody [EPR18344]

RabMAb|Recombinant|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-PRMT1 antibody [EPR18344] (AB190892)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMLKRKPSNVSEKEKHQKPKRSSSFGNFDRFRNNSLSKPDDSTEAHEGDPTNGSGEQSKTSNNGGGLGKKMRAISWTMKKKVGKKYIKALSEEKDEEDGENAHPYRNSDPVIGTHTEKVSLKASDSMDSLYSGQSSSSGITSCSDGTSNRDSFRLDDDGPYSGPFCGRARVHTDFTPSPYDTDSLKIKKGDIIDIICKTPMGMWTGMLNNKVGNFKFIYVDVISEEEAAPKKIKANRRSNSKKSKTLQEFLERIHLQEYTSTLLLNGYETLEDLKDIKESHLIELNIENPDDRRRLLSAAENFLEEEIIQEQENEPEPLSLSSDISLNKSQLDDCPRDSGCYISSGNSDNGKEDLESENLSDMVHKIIITEPSD","proteinLength":"Full Length","predictedMolecularWeight":"44.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":373,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9NSI8","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

SAMSN1 also known as HACS1 or SLY2 is a protein that functions primarily as an adapter protein involved in signal transduction. It has a mass of approximately 46 kDa. This protein is expressed in several tissues with high levels found in lymphoid organs like the spleen and peripheral blood leukocytes. SAMSN1 modulates protein-protein interactions through its SAM (sterile alpha motif) domain and a SH3 (Src homology 3) domain enabling it to interact with other critical proteins within cells.
Biological function summary

The function of SAMSN1 is essential in the immune response and cell signaling processes. It is part of signaling complexes that regulate immune cell function particularly B cells and T cells. By binding to other signaling proteins SAMSN1 can influence pathways that control cell growth differentiation and survival. This protein also participates in modulating transcription factors that are critical for immune cell maturation and function.

Pathways

SAMSN1 is significantly involved in the B-cell receptor signaling and the PI3K/Akt pathway. Through these pathways SAMSN1 affects the regulation of signal transduction cascades involved in cell proliferation and survival. It interacts with proteins such as PI3K and Akt which are significant in transducing signals that impact cellular responses to external stimuli.

SAMSN1 has been linked to autoimmune diseases and cancer. Altered expression of this protein can contribute to the development of conditions such as systemic lupus erythematosus and certain lymphomas. Interactions between SAMSN1 and proteins like BCR (B-cell receptor) play a role in the pathology of these disorders where dysregulation in signaling pathways may lead to the abnormal proliferation of immune cells or their improper functioning.
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일반 정보

기능

Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation (By similarity).

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제품 프로토콜

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타겟 정보

Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation (By similarity).
See full target information SAMSN1
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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