JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB276428

Recombinant Human SEMA4A protein (His tag)

Be the first to review this product! 리뷰 제출

|

(0 출판물)

Recombinant Human SEMA4A protein (His tag) is a Human Fragment protein, in the 1 to 683 aa range, expressed in HEK 293 cells, with 95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

대체 명칭 보기

SEMAB, SEMB, UNQ783/PRO1317, SEMA4A, Semaphorin-4A, Semaphorin-B, Sema B

1 이미지
SDS-PAGE - Recombinant Human SEMA4A protein (His tag) (AB276428)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human SEMA4A protein (His tag) (AB276428)

SDS-PAGE analysis of ab276428

주요 정보

Purity

95% HPLC

Endotoxin 레벨

< 1 EU/µg

발현 시스템

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 7.4 Constituents: PBS, 5% Trehalose

storage-buffer

style
left-column

보완 제품

Proteins & Peptides

AB162283

Recombinant Human OSGIN1 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human OSGIN1 protein (GST tag N-Terminus) (AB162283)

  • 0
  • 0
Primary Antibodies

AB70178

Anti-SEMA4A antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SEMA4A antibody (AB70178)

  • 0
  • 0
Proteins & Peptides

AB163809

Recombinant Human MS4A6A protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human MS4A6A protein (GST tag N-Terminus) (AB163809)

  • 0
  • 0
Proteins & Peptides

AB276342

Recombinant Human Neuropeptide Y protein (Fc Chimera)

SDS-PAGE - Recombinant Human Neuropeptide Y protein (Fc Chimera) (AB276342)

  • 0
  • 0
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

서열 정보

[{"linker":null,"sequence":"MALPALGLDPWSLLGLFLFQLLQLLLPTTTAGGGGQGPMPRVRYYAGDERRALSFFHQKGLQDFDTLLLSGDGNTLYVGAREAILALDIQDPGVPRLKNMIPWPASDRKKSECAFKKKSNETQCFNFIRVLVSYNVTHLYTCGTFAFSPACTFIELQDSYLLPISEDKVMEGKGQSPFDPAHKHTAVLVDGMLYSGTMNNFLGSEPILMRTLGSQPVLKTDNFLRWLHHDASFVAAIPSTQVVYFFFEETASEFDFFERLHTSRVARVCKNDVGGEKLLQKKWTTFLKAQLLCTQPGQLPFNVIRHAVLLPADSPTAPHIYAVFTSQWQVGGTRSSAVCAFSLLDIERVFKGKYKELNKETSRWTTYRGPETNPRPGSCSVGPSSDKALTFMKDHFLMDEQVVGTPLLVKSGVEYTRLAVETAQGLDGHSHLVMYLGTTTGSLHKAVVSGDSSAHLVEEIQLFPDPEPVRNLQLAPTQGAVFVGFSGGVWRVPRANCSVYESCVDCVLARDPHCAWDPESRTCCLLSAPNLNSWKQDMERGNPEWACASGPMSRSLRPQSRPQIIKEVLAVPNSILELPCPHLSALASYYWSHGPAAVPEASSTVYNGSLLLIVQDGVGGLYQCWATENGFSYPVISYWVDSQDQTLALDPELAGIPREHVKVPLTRVSGGAALAAQQSYWPH","proteinLength":"Fragment","predictedMolecularWeight":"73.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":683,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q9H3S1","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
style
left-column

특성 및 보관 정보

제형
Lyophilized
배송 시 보관 조건
Ambient - Can Ship with Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

SEMA4A also known as Semaphorin-4A is a protein that functions as a guidance cue in the immune and nervous systems. It has a molecular mass of approximately 85 kDa. SEMA4A is expressed in various tissues including the retina lung and thymus as well as in several immune cells such as T cells B cells and dendritic cells. This protein plays a significant role in cell signaling affecting cellular processes like axonal guidance and immune responses.
Biological function summary

The interaction of SEMA4A with its receptors such as Plexin B1 and TIM-2 mediates important cellular activities. It is part of the broader semaphorin family which has a role in directing axonal growth during development. This protein contributes to the regulation of immune cell activity including the activation and differentiation of T cells. The presence of SEMA4A influences immune responses highlighting its importance in maintaining immune system balance.

Pathways

SEMA4A engages in the immune system and axon guidance pathways. In the immune system it interacts with proteins like Plexin B1 and CD72 influencing T cell proliferation and function. Through the axon guidance pathway SEMA4A helps direct the growth of nerve fibers impacting neuronal circuit formation. These interactions exemplify SEMA4A's role in linking cell signaling with physiological outcomes.

SEMA4A has connections with retinal degenerative diseases and immune system disorders. Mutations in the SEMA4A gene have been associated with retinitis pigmentosa a retinal disorder leading to vision loss. SEMA4A also plays a role in autoimmune diseases where its interaction with receptors like Plexin B1 affects immune cell function. Understanding the involvement of SEMA4A in these conditions helps in developing potential therapeutic approaches targeting its signaling pathways.
style
left-column

일반 정보

기능

Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling (By similarity). Regulates glutamatergic and GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner and promotes the development of excitatory synapses in a PLXNB2-dependent manner (By similarity). Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity (By similarity). Promotes phosphorylation of TIMD2 (By similarity). Inhibits angiogenesis (By similarity). Promotes axon growth cone collapse (By similarity). Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (By similarity).

서열 유사성

Belongs to the semaphorin family.

style
left-column

제품 프로토콜

style
left-column

타겟 정보

Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling (By similarity). Regulates glutamatergic and GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner and promotes the development of excitatory synapses in a PLXNB2-dependent manner (By similarity). Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity (By similarity). Promotes phosphorylation of TIMD2 (By similarity). Inhibits angiogenesis (By similarity). Promotes axon growth cone collapse (By similarity). Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (By similarity).
See full target information SEMA4A
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com