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AB276350

Recombinant Human SERPINI2 protein (His tag)

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Recombinant Human SERPINI2 protein (His tag) is a Human Full Length protein, in the 1 to 405 aa range, expressed in HEK 293 cells, with >90%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

대체 명칭 보기

MEPI, PI14, SERPINI2, Serpin I2, Myoepithelium-derived serine protease inhibitor, Pancpin, Pancreas-specific protein TSA2004, Peptidase inhibitor 14, PI-14

1 이미지
SDS-PAGE - Recombinant Human SERPINI2 protein (His tag) (AB276350)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human SERPINI2 protein (His tag) (AB276350)

SDS-PAGE analysis of ab276350

주요 정보

Purity

>90% SDS-PAGE

Endotoxin 레벨

< 1 EU/µg

발현 시스템

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 7.4 Constituents: PBS

storage-buffer

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보완 제품

Proteins & Peptides

AB139238

Recombinant Human FDCSP protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human FDCSP protein (His tag N-Terminus) (AB139238)

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Proteins & Peptides

AB106888

Recombinant E. coli cysH protein (His tag N-Terminus)

SDS-PAGE - Recombinant E. coli cysH protein (His tag N-Terminus) (AB106888)

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Proteins & Peptides

AB157846

Recombinant Human Activin A Receptor Type IB/ALK-4 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human Activin A Receptor Type IB/ALK-4 protein (GST tag N-Terminus) (AB157846)

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Proteins & Peptides

AB276351

Recombinant Human ANGPTL2/ARP2 protein (His tag)

SDS-PAGE - Recombinant Human ANGPTL2/ARP2 protein (His tag) (AB276351)

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MDTIFLWSLLLLFFGSQASRCSAQKNTEFAVDLYQEVSLSHKDNIIFSPLGITLVLEMVQLGAKGKAQQQIRQTLKQQETSAGEEFFVLKSFFSAISEKKQEFTFNLANALYLQEGFTVKEQYLHGNKEFFQSAIKLVDFQDAKACAEMISTWVERKTDGKIKDMFSGEEFGPLTRLVLVNAIYFKGDWKQKFRKEDTQLINFTKKNGSTVKIPMMKALLRTKYGYFSESSLNYQVLELSYKGDEFSLIIILPAEGMDIEEVEKLITAQQILKWLSEMQEEEVEISLPRFKVEQKVDFKDVLYSLNITEIFSGGCDLSGITDSSEVYVSQVTQKVFFEINEDGSEAATSTGIHIPVIMSLAQSQFIANHPFLFIMKHNPTESILFMGRVTNPDTQEIKGRDLDSL","proteinLength":"Full Length","predictedMolecularWeight":"45.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":405,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"O75830","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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특성 및 보관 정보

제형
Lyophilized
배송 시 보관 조건
Ambient - Can Ship with Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

SERPINI2 also known as Neuroserpin is a serine protease inhibitor with a molecular weight of approximately 44 kDa. This protein plays an important role in inhibiting proteolytic enzymes in the nervous system and other tissues. It is primarily expressed in the pancreas but it is also found in the central nervous system particularly in organs like the brain and spinal cord. The protein showcases moderate expression in tissues including lungs and kidneys reflecting its widespread regulatory functions across diverse physiological environments.
Biological function summary

SERPINI2 interacts closely with serine proteases like tissue plasminogen activator to maintain cellular homeostasis by preventing excessive proteolysis. This regulatory action is important in processes such as fibrotic response maintaining extracellular matrix integrity and facilitating normal cellular turnover. SERPINI2 operates by forming complexes with its target proteins inhibiting their proteolytic activity and therefore modulating various cellular activities especially where proteolysis needs to be checked to prevent tissue damage.

Pathways

SERPINI2 finds itself involved in regulatory pathways including the fibrinolytic system and the inflammatory response system. Its modulation of plasminogen activator activity links SERPINI2 to the plasminogen activation pathway essential for processes like tissue remodeling and repair. Additionally it shares functional interactions with proteins like plasminogen activator inhibitor 1 (PAI-1) working in tandem to optimize fibrinolytic balance and influence the turnover of the extracellular matrix.

SERPINI2 has been implicated in conditions such as pancreatic cancer and respiratory diseases like chronic obstructive pulmonary disease (COPD). In pancreatic cancer altered regulation of SERPINI2 has been associated with tumor progression due to changes in proteolytic control within the tumor microenvironment. Furthermore in respiratory disorders it connects to proteins like alpha-1-antitrypsin where dysregulated protease inhibition can exacerbate tissue destruction and inflammation common features of COPD.
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일반 정보

서열 유사성

Belongs to the serpin family.

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제품 프로토콜

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타겟 정보

See full target information SERPINI2
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Product promise

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