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AB239446

Recombinant Human SET7 protein (Tagged)

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Recombinant Human SET7 protein (Tagged) is a Human Fragment protein, in the 110 to 366 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

대체 명칭 보기

KIAA1717, KMT7, SET7, SET9, SETD7, Histone-lysine N-methyltransferase SETD7, Histone H3-K4 methyltransferase SETD7, Lysine N-methyltransferase 7, SET domain-containing protein 7, SET7/9, H3-K4-HMTase SETD7

1 이미지
SDS-PAGE - Recombinant Human SET7 protein (Tagged) (AB239446)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human SET7 protein (Tagged) (AB239446)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) analysis with 5% enrichment gel and 15% separation gel analysis of ab239446.

주요 정보

Purity

>85% SDS-PAGE

발현 시스템

Escherichia coli

Tags

10x His tag N-Terminus SUMO tag N-Terminus Myc tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

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보완 제품

Primary Antibodies

AB124708

Anti-SET7 antibody [EPR5574]

RabMAb|Recombinant|KO Validated

Immunoprecipitation - Anti-SET7 antibody [EPR5574] (AB124708)

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Recombinant Human TNFAIP3 Protein

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Recombinant human TNF alpha protein (Active)

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"YKDNIRHGVCWIYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGKLATLMSTEEGRPHFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYVAESLISSAGEGLFSKVAVGPNTVMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFTPNCIYDMFVHPRFGPIKCIRTLRAVEADEELTVAYGYDHSPPGKSGPEAPEWYQVELKAFQATQQK","proteinLength":"Fragment","predictedMolecularWeight":"48.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":366,"aminoAcidStart":110,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q8WTS6","tags":[{"tag":"10x His","terminus":"N-Terminus"},{"tag":"SUMO","terminus":"N-Terminus"},{"tag":"Myc","terminus":"C-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

SET7 also known as SETD7 or KMT7 is a lysine methyltransferase that adds methyl groups to lysine residues on target proteins influencing their function and stability. This protein has a molecular mass of approximately 55 kDa. SET7 is expressed in a variety of tissues including the heart liver and pancreas suggesting its versatile role across different biological systems.
Biological function summary

SET7 contributes to gene regulation by methylating histone H3 at lysine 4 (H3K4) a mark generally associated with transcriptional activation. It also methylates non-histone proteins such as p53 TAF10 and STAT3 affecting their activity and interactions. SET7 operates distinctively and does not need to be part of any complex to fulfill its function effectively in diverse cellular processes.

Pathways

SET7 modulates transcriptional pathways such as the p53 signaling pathway and the NF-kB pathway. It interacts with the p53 protein affecting cell cycle regulation and the response to DNA damage. The modification of NF-kB by SET7 can influence inflammation and immune responses. Through these pathways SET7 plays a role in maintaining cellular homeostasis and response to stress.

SET7 is involved in conditions like cancer and cardiovascular diseases. Its methylation of p53 links it to tumor suppression activities while its impact on NF-kB relates to inflammatory responses. Dysregulation of SET7 activity can lead to abnormal cell proliferation and inflammation pointing to its potential as a target for therapeutic intervention.
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일반 정보

기능

Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3 (PubMed : 11779497, PubMed : 11850410, PubMed : 12540855, PubMed : 12588998, PubMed : 16141209). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed : 12540855, PubMed : 12588998, PubMed : 16141209). Plays a central role in the transcriptional activation of genes such as collagenase or insulin (PubMed : 12588998, PubMed : 16141209). Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription (PubMed : 16141209). Also has methyltransferase activity toward non-histone proteins such as CGAS, p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins (PubMed : 15099517, PubMed : 15525938, PubMed : 16415881, PubMed : 35210392). Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II (PubMed : 15099517, PubMed : 16415881). Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation (PubMed : 15525938, PubMed : 16415881, PubMed : 17108971). Monomethylates 'Lys-491' of CGAS, promoting interaction between SGF29 and CGAS (By similarity).

서열 유사성

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET7 subfamily.

Subcellular localisation

Nucleus

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제품 프로토콜

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타겟 정보

Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3 (PubMed : 11779497, PubMed : 11850410, PubMed : 12540855, PubMed : 12588998, PubMed : 16141209). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed : 12540855, PubMed : 12588998, PubMed : 16141209). Plays a central role in the transcriptional activation of genes such as collagenase or insulin (PubMed : 12588998, PubMed : 16141209). Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription (PubMed : 16141209). Also has methyltransferase activity toward non-histone proteins such as CGAS, p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins (PubMed : 15099517, PubMed : 15525938, PubMed : 16415881, PubMed : 35210392). Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II (PubMed : 15099517, PubMed : 16415881). Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation (PubMed : 15525938, PubMed : 16415881, PubMed : 17108971). Monomethylates 'Lys-491' of CGAS, promoting interaction between SGF29 and CGAS (By similarity).
See full target information SETD7
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Product promise

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