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AB124551

Recombinant Human SH3GL2 protein (His tag N-Terminus)

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Recombinant Human SH3GL2 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 352 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.

대체 명칭 보기

CNSA2, SH3D2A, SH3GL2, Endophilin-A1, EEN-B1, Endophilin-1, SH3 domain protein 2A, SH3 domain-containing GRB2-like protein 2

1 이미지
SDS-PAGE - Recombinant Human SH3GL2 protein (His tag N-Terminus) (AB124551)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human SH3GL2 protein (His tag N-Terminus) (AB124551)

15% SDS-PAGE (3 µg loaded)

주요 정보

Purity

>85% SDS-PAGE

Purified by using conventional chromatography techniques.

발현 시스템

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.32% Tris HCl, 0.29% Sodium chloride, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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보완 제품

Primary Antibodies

AB137321

Anti-Vimentin antibody

Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Vimentin antibody (AB137321)

  • 5
  • 1
Primary Antibodies

AB76011

Anti-N Cadherin antibody [EPR1791-4]

20ul selling size|RabMAb|Recombinant|KO Validated

Western blot - Anti-N Cadherin antibody [EPR1791-4] (AB76011)

  • 4
  • 14
Primary Antibodies

AB150431

Anti-SH3GL1 + SH3GL2 + SH3GL3 antibody [EPR10215(B)]

20ul selling size|RabMAb|Recombinant

Western blot - Anti-SH3GL1 + SH3GL2 + SH3GL3 antibody [EPR10215(B)] (AB150431)

  • 0
  • 0
Primary Antibodies

AB308347

Anti-E Cadherin antibody [HL1229]

Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-E Cadherin antibody [HL1229] (AB308347)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMGSHMSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMRELSEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRLEERIRQASSQPRREYQPKPRMSLEFPTGDSTQPNGGLSHTGTPKPSGVQMDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEILVALPH","proteinLength":"Full Length","predictedMolecularWeight":"42.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":352,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q99962","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

SH3GL2 also known as Endophilin A1 is a protein that plays an important role in membrane dynamics during endocytosis. It has a molecular weight of approximately 41 kDa. Mechanically SH3GL2 binds to lipids and helps in membrane curvature due to its BAR domain. This protein is highly expressed in neuronal tissues where it participates in synaptic vesicle endocytosis. It interacts with other proteins via its SH3 domain facilitating the assembly of protein complexes involved in these cellular processes.
Biological function summary

SH3GL2 is involved in synaptic vesicle recycling an important process for neurocommunication. It is part of a complex that includes proteins such as dynamin and synaptojanin. It ensures the rapid turnover of synaptic vesicles by mediating their endocytosis and recycling back to the synaptic terminal. This function helps in maintaining efficient synaptic transmission essential for neuronal communication and plasticity.

Pathways

SH3GL2 is involved in the clathrin-mediated endocytosis pathway. This pathway is critical for the retrieval of synaptic vesicles in neurons. SH3GL2 works closely with clathrin and dynamin to facilitate the budding and scission of vesicles from the plasma membrane. In addition SH3GL2 also interacts within the synaptic vesicle cycle ensuring the availability of vesicles for neurotransmitter release.

SH3GL2 has been linked to neurodegenerative diseases such as Parkinson's disease. Its interaction with proteins like alpha-synuclein suggests its role in the pathogenesis of this disorder. Altered SH3GL2 function may disrupt normal synaptic vesicle dynamics contributing to neuronal dysfunction. Furthermore aberrant SH3GL2 expression or function may also be involved in schizoaffective disorders where its interaction with synaptojanin plays a role in synaptic dysfunction.
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일반 정보

기능

Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes.

서열 유사성

Belongs to the endophilin family.

Subcellular localisation

Early endosome

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제품 프로토콜

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타겟 정보

Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes.
See full target information SH3GL2
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Product promise

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