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AB222994

Recombinant Human SIGLEC9 protein (Fc tag C-Terminus + His tag C-Terminus)

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Recombinant Human SIGLEC9 protein (Fc tag C-Terminus + His tag C-Terminus) is a Human Fragment protein, in the 18 to 348 aa range, expressed in Baculovirus infected insect cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

대체 명칭 보기

CD329, UNQ668/PRO1302, SIGLEC9, Sialic acid-binding Ig-like lectin 9, Siglec-9, CDw329, Protein FOAP-9

1 이미지
SDS-PAGE - Recombinant Human SIGLEC9 protein (Fc tag C-Terminus + His tag C-Terminus) (AB222994)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human SIGLEC9 protein (Fc tag C-Terminus + His tag C-Terminus) (AB222994)

3μg of ab222994 was analysed by 15% SDS-PAGE.

주요 정보

Purity

>95% SDS-PAGE

Affinity purified

Endotoxin 레벨

< 1 EU/µg

발현 시스템

Baculovirus infected insect cells

Tags

Fc tag C-Terminus His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 7.4 Constituents: PBS, 10% Glycerol (glycerin, glycerine)

storage-buffer

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보완 제품

Proteins & Peptides

AB307793

Recombinant Human Siglec 7 Protein (Fc-tag)

Mass Spectrometry - Recombinant Human Siglec 7 Protein (Fc-tag) (AB307793)

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  • 0
Proteins & Peptides

AB276607

Recombinant Human SIGLEC15 protein (His tag)

SDS-PAGE - Recombinant Human SIGLEC15 protein (His tag) (AB276607)

  • 0
  • 0
Primary Antibodies

AB9572

Anti-IGF1+IGF2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IGF1+IGF2 antibody (AB9572)

  • 4
  • 8
Primary Antibodies

AB197981

Anti-SIGLEC9 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SIGLEC9 antibody (AB197981)

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  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"ADPQTSKLLTMQSSVTVQEGLCVHVPCSFSYPSHGWIYPGPVVHGYWFREGANTDQDAPVATNNPARAVWEETRDRFHLLGDPHTKNCTLSIRDARRSDAGRYFFRMEKGSIKWNYKHHRLSVNVTALTHRPNILIPGTLESGCPQNLTCSVPWACEQGTPPMISWIGTSVSPLDPSTTRSSVLTLIPQPQDHGTSLTCQVTFPGASVTTNKTVHLNVSYPPQNLTMTVFQGDGTVSTVLGNGSSLSLPEGQSLRLVCAVDAVDSNPPARLSLSWRGLTLCPSQPSNPGVLELPWVHLRDAAEFTCRAQNPLGSQQVYLNVSLQSKATSGVTQGLEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKHHHHHH","proteinLength":"Fragment","predictedMolecularWeight":"66.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":348,"aminoAcidStart":18,"nature":"Recombinant","expressionSystem":"Baculovirus infected insect cells","accessionNumber":"Q9Y336","tags":[{"tag":"Fc","terminus":"C-Terminus"},{"tag":"His","terminus":"C-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

SIGLEC9 also known as Sialic acid-binding Ig-like lectin 9 is a protein that plays a mechanical role in recognizing sialic acid-containing glycoproteins. It acts as an inhibitory receptor found on the surface of various immune cells primarily myeloid cells like neutrophils and monocytes. SIGLEC9 has a molecular weight of around 65 kilodaltons. This protein is predominantly expressed in hematopoietic tissues such as the spleen and bone marrow where the immune cells are common.
Biological function summary

This protein is involved in immune regulation helping to modulate immune responses and maintain self-tolerance to prevent autoimmunity. SIGLEC9 can recognize sialylated ligands on cell surfaces and interact with them to down-modulate immune cell activation. This protein is not known to be part of a specific complex but interacts directly with ligands on other cells influencing cellular communication and immune cell signaling within the microenvironment.

Pathways

SIGLEC9 participates primarily in the immune response pathway and interacts with pathways related to inflammation regulation. It works alongside proteins such as SIRPα which also plays a role in signaling pathways that result in immune cell inhibition. This coordination is critical to suppressing overactive immune responses and ensuring damage does not occur to host tissues during inflammation.

SIGLEC9 has been linked to chronic inflammatory conditions and autoimmune diseases. Its inhibitory function suggests that alterations in SIGLEC9 expression or function could contribute to disorders such as rheumatoid arthritis. Additionally SIGLEC9 might interact with proteins like CD33 which is implicated in similar immune response pathways. Targeting SIGLEC9 offers potential avenues for therapeutic intervention in diseases characterized by dysregulated immune responses.
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일반 정보

기능

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

서열 유사성

Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.

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제품 프로토콜

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타겟 정보

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
See full target information SIGLEC9
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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