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AB235876

Recombinant Human SIRPB1 protein (His tag C-Terminus)

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Recombinant Human SIRPB1 protein (His tag C-Terminus) is a Human Fragment protein, in the 30 to 371 aa range, expressed in Baculovirus infected insect cells, with >90%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

대체 명칭 보기

CD172b, Signal-regulatory protein beta-1, SIRP-beta-1, CD172 antigen-like family member B, SIRPB1

1 이미지
SDS-PAGE - Recombinant Human SIRPB1 protein (His tag C-Terminus) (AB235876)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human SIRPB1 protein (His tag C-Terminus) (AB235876)

15% SDS-PADE analysis of 3 μg ab235876.

주요 정보

Purity

>90% SDS-PAGE

ab235876 was expressed in insect cell and affinity purified.

Endotoxin 레벨

< 1 EU/µg

발현 시스템

Baculovirus infected insect cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 7.4 Constituents: PBS, 10% Glycerol (glycerin, glycerine)

storage-buffer

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보완 제품

Primary Antibodies

AB234681

Anti-SIRPB1 antibody

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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제품 세부 정보

This product was previously labelled as SIRP beta 1/CD172b
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서열 정보

[{"linker":null,"sequence":"EDELQVIQPEKSVSVAAGESATLRCAMTSLIPVGPIMWFRGAGAGRELIYNQKEGHFPRVTTVSELTKRNNLDFSISISNITPADAGTYYCVKFRKGSPDDVEFKSGAGTELSVRAKPSAPVVSGPAVRATPEHTVSFTCESHGFSPRDITLKWFKNGNELSDFQTNVDPAGDSVSYSIHSTARVVLTRGDVHSQVICEIAHITLQGDPLRGTANLSEAIRVPPTLEVTQQPMRAENQANVTCQVSNFYPRGLQLTWLENGNVSRTETASTLIENKDGTYNWMSWLLVNTCAHRDDVVLTCQVEHDGQQAVSKSYALEISAHQKEHGSDITHEAALAPTAPLHHHHHH","proteinLength":"Fragment","predictedMolecularWeight":"38 kDa","actualMolecularWeight":null,"aminoAcidEnd":371,"aminoAcidStart":30,"nature":"Recombinant","expressionSystem":"Baculovirus infected insect cells","accessionNumber":"O00241","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Signal regulatory protein beta-1 (SIRPB1) also known as CD172b is a transmembrane glycoprotein that functions as an inhibitory receptor. It weighs about 55 kDa. SIRPB1 is mainly expressed on myeloid cells including monocytes macrophages and granulocytes. It contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) which recruits phosphatases such as Src homology region 2 domain-containing phosphatase-1 (SHP-1) upon phosphorylation. This motif plays an important role in mediating inhibitory signals inside the cell.
Biological function summary

Within the immune system context SIRPB1 acts to regulate functions related to myeloid cells. It does not form part of a larger receptor complex but significantly influences cell communication. It modulates responses like phagocytosis and cellular activation maintaining balanced immune reactions. The interaction with its ligands like CD47 or DAP12 provides insights into its ability to send inhibitory signals contributing to the overall control of immune responses.

Pathways

SIRPB1 gets involved in immune regulation and signal transduction. It plays a significant role in the CD47-SIRP signaling pathway which affects processes like cell migration and phagocytosis. The interaction with SHP-1 and SHP-2 phosphatases signifies its integration within signaling networks governing negative regulation of cellular activation. Through these pathways SIRPB1 interacts with related proteins like SIRPA and SIRPG which have similar functions yet distinct roles within the immune system.

SIRPB1 has associations with inflammatory conditions and cancer. In inflammatory disorders like rheumatoid arthritis altered expression of SIRPB1 can contribute to pathogenesis by modifying immune cell activation further linking it with SIRPA in the modulation of immune responses. In cancer SIRPB1's role extends to tumor immune evasion where upregulated CD47 affects SIRPB1 pathways to inhibit phagocytosis by macrophages influencing tumor progression. Understanding SIRPB1's connections with these proteins and pathways opens avenues for therapeutic interventions in these diseases.
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일반 정보

기능

Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Also participates in the recruitment of tyrosine kinase SYK. Triggers activation of myeloid cells when associated with TYROBP (PubMed : 10604985).

Post-translational modifications

N-glycosylated.

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제품 프로토콜

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타겟 정보

Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Also participates in the recruitment of tyrosine kinase SYK. Triggers activation of myeloid cells when associated with TYROBP (PubMed : 10604985).
See full target information Signal-regulatory protein beta-1
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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