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AB152862

Recombinant Human SLC25A11 protein (GST tag N-Terminus)

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(1 출판물)

Recombinant Human SLC25A11 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 314 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

대체 명칭 보기

SLC20A4, SLC25A11, Mitochondrial 2-oxoglutarate/malate carrier protein, Alpha-oxoglutarate carrier, OGCP, Solute carrier family 25 member 11

1 이미지
SDS-PAGE - Recombinant Human SLC25A11 protein (GST tag N-Terminus) (AB152862)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human SLC25A11 protein (GST tag N-Terminus) (AB152862)

12.5% SDS-PAGE analysis of ab152862 stained with Coomassie Blue.

주요 정보

발현 시스템

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, SDS-PAGE, ELISA

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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보완 제품

Secondary Antibodies

AB205718

Goat Anti-Rabbit IgG H&L (HRP)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Goat Anti-Rabbit IgG H&L (HRP) (AB205718)

  • 5
  • 8
Primary Antibodies

AB317695

Anti-Sarcomeric Alpha Actinin antibody [EPR28776-83]

BOND RX™ Validated|20ul selling size|Recombinant|RabMAb

Immunocytochemistry/ Immunofluorescence - Anti-Sarcomeric Alpha Actinin antibody [EPR28776-83] (AB317695)

  • 0
  • 0
Primary Antibodies

AB275391

Anti-Dystrophin antibody [EPR23336-129]

BOND RX™ Validated|20ul selling size|Recombinant|Advanced Validation|RabMAb|KO Validated|Trial Size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Dystrophin antibody [EPR23336-129] (AB275391)

  • 0
  • 0
Primary Antibodies

AB52862

Anti-Cardiac Troponin I antibody [EP1106Y]

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Flow Cytometry (Intracellular) - Anti-Cardiac Troponin I antibody [EP1106Y] (AB52862)

  • 5
  • 2
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MAATASAGAGGIDGKPRTSPKSVKFLFGGLAGMGATVFVQPLDLVKNRMQLSGEGAKTREYKTSFHALTSILKAEGLRGIYTGLSAGLLRQATYTTTRLGIYTVLFERLTGADGTPPGFLLKAVIGMTAGATGAFVGTPAEVALIRMTADGRLPADQRRGYKNVFNALIRITREEGVLTLWRGCIPTMARAVVVNAAQLASYSQSKQFLLDSGYFSDNILCHFCASMISGLVTTAASMPVDIAKTRIQNMRMIDGKPEYKNGLDVLFKVVRYEGFFSLWKGFTPYYARLGPHTVLTFIFLEQMNKAYKRLFLSG","proteinLength":"Full Length","predictedMolecularWeight":"60.28 kDa","actualMolecularWeight":null,"aminoAcidEnd":314,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q02978","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Proprietary technique
배송 시 보관 조건
Dry Ice
적절한 단기 보관 조건
-80°C
적절한 장기 보관 조건
-80°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The SLC25A11 protein also known as the mitochondrial 2-oxoglutarate/malate carrier protein plays an important role in transporting substrates across the inner mitochondrial membrane. It specifically facilitates the exchange of 2-oxoglutarate and malate between the mitochondria and the cytosol. SLC25A11 has a molecular mass of approximately 33 kDa. Expression of SLC25A11 occurs across various tissues with significant levels in the liver and skeletal muscle where high energy turnover is required.
Biological function summary

SLC25A11 is integral to mitochondrial function and energy metabolism. It is part of a transporter complex involved in the tricarboxylic acid (TCA) cycle supporting the conversion of nutrients into energy. This process is essential for maintaining the cellular energy levels needed for various physiological functions. The efficient transport of 2-oxoglutarate and malate helps in balancing the redox and carbon status in cells contributing to overall cellular homeostasis.

Pathways

SLC25A11 is essential in the TCA cycle and the malate-aspartate shuttle. These pathways are vital for energy production and the regulation of cellular metabolism. In the TCA cycle SLC25A11 works closely with other proteins like isocitrate dehydrogenase participating in the decarboxylation and oxidation processes. In the malate-aspartate shuttle SLC25A11 collaborates with malate dehydrogenase enabling effective NADH transfer into the mitochondria a critical step for ATP generation.

SLC25A11 is linked to metabolic and mitochondrial disorders. Mutations or dysfunction in SLC25A11 can contribute to conditions such as mitochondrial diseases where energy production is impaired. This protein also shows associations with some forms of cancer where altered metabolism is a hallmark. Connections with other proteins like fumarate hydratase highlight its role in pathways that when disrupted may lead to disease progression.
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일반 정보

기능

Catalyzes the transport of 2-oxoglutarate (alpha-oxoglutarate) across the inner mitochondrial membrane in an electroneutral exchange for malate (PubMed : 25637873, PubMed : 38937634). Can also exchange 2-oxoglutarate for other dicarboxylic acids such as malonate, succinate, maleate and oxaloacetate, although with lower affinity (By similarity). Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction (PubMed : 38937634). Does not transport glutathione (PubMed : 25637873). Contributes to several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, gluconeogenesis from lactate, and nitrogen metabolism (By similarity). Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae (PubMed : 21448454). Involved in the regulation of apoptosis (By similarity).

서열 유사성

Belongs to the mitochondrial carrier (TC 2.A.29) family.

Subcellular localisation

Mitochondrion inner membrane

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제품 프로토콜

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타겟 정보

Catalyzes the transport of 2-oxoglutarate (alpha-oxoglutarate) across the inner mitochondrial membrane in an electroneutral exchange for malate (PubMed : 25637873, PubMed : 38937634). Can also exchange 2-oxoglutarate for other dicarboxylic acids such as malonate, succinate, maleate and oxaloacetate, although with lower affinity (By similarity). Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction (PubMed : 38937634). Does not transport glutathione (PubMed : 25637873). Contributes to several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, gluconeogenesis from lactate, and nitrogen metabolism (By similarity). Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae (PubMed : 21448454). Involved in the regulation of apoptosis (By similarity).
See full target information SLC25A11
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Molecular therapy. Nucleic acids 34:102060 PubMed38028197

2023

Efficacy of exon-skipping therapy for DMD cardiomyopathy with mutations in actin binding domain 1.

Applications

Unspecified application

Species

Unspecified reactive species

Naoko Shiba,Xiao Yang,Mitsuto Sato,Shin Kadota,Yota Suzuki,Masahiro Agata,Kohei Nagamine,Masaki Izumi,Yusuke Honda,Tomoya Koganehira,Hideki Kobayashi,Hajime Ichimura,Shinichiro Chuma,Junichi Nakai,Shugo Tohyama,Keiichi Fukuda,Daigo Miyazaki,Akinori Nakamura,Yuji Shiba
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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