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AB276453

Recombinant Human SMOC1 protein (His tag)

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Recombinant Human SMOC1 protein (His tag) is a Human Fragment protein, in the 1 to 435 aa range, expressed in HEK 293 cells, with >92%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

대체 명칭 보기

SPARC-related modular calcium-binding protein 1, Secreted modular calcium-binding protein 1, SMOC-1, SMOC1

1 이미지
SDS-PAGE - Recombinant Human SMOC1 protein (His tag) (AB276453)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human SMOC1 protein (His tag) (AB276453)

SDS-PAGE analysis of ab276453.

주요 정보

Purity

>92% SDS-PAGE

Endotoxin 레벨

< 1 EU/µg

발현 시스템

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 7.4 Constituents: PBS

storage-buffer

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보완 제품

Reagents, Controls & Accessories

AB133411

Low Fluorescence Western Membrane (PVDF)

  • 5
  • 1
Primary Antibodies

AB200219

Anti-SMOC1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SMOC1 antibody (AB200219)

  • 0
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Assay Kits

AB309579

Human SMOC1 Antibody Pair - BSA and Azide free

RabMAb|Recombinant

Sandwich ELISA - Human SMOC1 Antibody Pair - BSA and Azide free (AB309579)

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Proteins & Peptides

AB53869

Recombinant Human 14-3-3 gamma/YWHAG protein (Tag Free)

SDS-PAGE - Recombinant Human 14-3-3 gamma/YWHAG protein (Tag Free) (AB53869)

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  • 0
Proteins & Peptides

AB269022

Recombinant Human Tau (phospho ) protein (Tag Free)

SDS-PAGE - Recombinant Human Tau (phospho ) protein (AB269022)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MLPARCARLLTPHLLLVLVQLSPARGHRTTGPRFLISDRDPQCNLHCSRTQPKPICASDGRSYESMCEYQRAKCRDPTLGVVHRGRCKDAGQSKCRLERAQALEQAKKPQEAVFVPECGEDGSFTQVQCHTYTGYCWCVTPDGKPISGSSVQNKTPVCSGSVTDKPLSQGNSGRKDDGSKPTPTMETQPVFDGDEITAPTLWIKHLVIKDSKLNNTNIRNSEKVYSCDQERQSALEEAQQNPREGIVIPECAPGGLYKPVQCHQSTGYCWCVLVDTGRPLPGTSTRYVMPSCESDARAKTTEADDPFKDRELPGCPEGKKMEFITSLLDALTTDMVQAINSAAPTGGGRFSEPDPSHTLEERVVHWYFSQLDSNSSNDINKREMKPFKRYVKKKAKPKKCARRFTDYCDLNKDKVISLPELKGCLGVSKEVGRLV","proteinLength":"Fragment","predictedMolecularWeight":"47 kDa","actualMolecularWeight":null,"aminoAcidEnd":435,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q9H4F8","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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특성 및 보관 정보

제형
Lyophilized
배송 시 보관 조건
Ambient - Can Ship with Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

SPARC-related modular calcium binding 1 (SMOC1) is an extracellular matrix protein coded by the SMOC1 gene. Known also as its full form the protein weighs approximately 59 kDa and consists of several domains including a thyroglobulin type-1 repeat and two EF-hand domains. SMOC1 is widely expressed in various tissues such as the eye bone and skin. Its expression pattern suggests it plays an important role in tissue development and maintenance.
Biological function summary

SMOC1 functions involve regulation of angiogenesis and cellular differentiation. It interacts with the extracellular matrix modulating the assembly and dynamics of structural proteins. SMOC1 sounds interactions with calmodulin and integrins forming part of a larger complex. This complex engagement influences cellular processes like cell migration adhesion and stabilization which are pivotal for development and wound healing.

Pathways

SMOC1 associates with integrin signaling and TGF-beta signaling pathways. These pathways govern processes like cell growth apoptosis and differentiation. SMOC1 modulates the activity of integrins connecting with proteins such as integrin alpha-V beta-3 and transforming growth factor beta (TGF-β). Their relationships indicate SMOC1's involvement in cellular communication and response to environmental changes.

SMOC1 links to conditions like microphthalmia and coloboma as well as bone development disorders. Mutations or dysregulation of SMOC1 impairs normal development indicating its role in ocular and skeletal health. Researchers note connections with proteins like Pax6 which is also involved in eye development. This involvement shows how closely SMOC1 is tied to disorders affecting vision and structural integrity.
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일반 정보

기능

Plays essential roles in both eye and limb development. Probable regulator of osteoblast differentiation.

Post-translational modifications

Glycosylated.

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제품 프로토콜

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타겟 정보

Plays essential roles in both eye and limb development. Probable regulator of osteoblast differentiation.
See full target information SMOC1
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Acta neuropathologica 148:72 PubMed39585417

2024

SMOC1 colocalizes with Alzheimer's disease neuropathology and delays Aβ aggregation.

Applications

Unspecified application

Species

Unspecified reactive species

Kaleah Balcomb,Caitlin Johnston,Tomas Kavanagh,Dominique Leitner,Julie Schneider,Glenda Halliday,Thomas Wisniewski,Margaret Sunde,Eleanor Drummond
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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