Recombinant Human Spermidine synthase protein (His tag N-Terminus)

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Biological function summary

Spermidine synthase plays a critical role in the synthesis of polyamines such as spermine which are vital for cell growth and differentiation. Polyamines stabilize DNA structure modulate ion channels and aid in gene expression. Spermidine synthase operates as a standalone enzyme and is not part of a multi-protein complex. Its expression levels and activity are tightly regulated reflecting its importance in cellular homeostasis and response to stress.

Pathways

Spermidine synthase is central to the polyamine biosynthesis pathway which is important for cellular proliferation. In this pathway it acts after ornithine decarboxylase converting putrescine to spermidine and before spermine synthase which produces spermine from spermidine. Spermidine synthase is also involved in the regulation of eukaryotic translation initiation highlighting its influence on protein biosynthesis and cell growth.