Recombinant Human ST2 protein (Active)
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Recombinant Human ST2 protein (Active) is a Human Fragment protein, in the 19 to 328 aa range, expressed in HEK 293 cells, with >95%, suitable for SDS-PAGE, FuncS.
대체 명칭 보기
DER4, ST2, T1, IL1RL1, Interleukin-1 receptor-like 1, Protein ST2
- FuncS
Supplier Data
Functional Studies - Recombinant Human ST2 protein (Active) (AB283466)
Fully biologically active determined by its ability to inhibit IL-33 dependent proliferation of D10S cells. The ED50 ≤ 0.27 µg/ml, corresponding to a specific activity of 3.7 x 10^3 units/mg.
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human ST2 protein (Active) (AB283466)
SDS-page analysis of ab283466
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서열 정보
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추가 정보
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
ST2 interacts with interleukin-33 (IL-33) and functions as its receptor. The binding of IL-33 to ST2 activates immune responses particularly influencing T-helper 2 (Th2) cells. ST2 forms part of a receptor complex including IL-1 receptor accessory protein IL-1RAcP necessary for signal transduction. This interaction leads to the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) and mitogen-activated protein kinase (MAPK) signaling pathways facilitating inflammatory responses.
Pathways
IL-33 signals through the ST2 receptor participating actively in the immune signaling pathway. This pathway plays a significant role in modulating inflammatory and immune responses. ST2 association with NF-kB broadly affects inflammatory signaling while its involvement with the MAPK pathway aids in cellular responses to cytokines and stress. The close relationship with the IL-33/ST2 axis highlights its importance in maintaining immune homeostasis and reacting to environmental stressors.
일반 정보
기능
Receptor for interleukin-33 (IL-33) which plays crucial roles in innate and adaptive immunity, contributing to tissue homeostasis and responses to environmental stresses together with coreceptor IL1RAP (PubMed : 35238669). Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function (Probable) (PubMed : 16286016). Upon tissue injury, induces UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages (By similarity).. Isoform B. Inhibits IL-33 signaling.
서열 유사성
Belongs to the interleukin-1 receptor family.
Post-translational modifications
Ubiquitinated at Lys-321 in a FBXL19-mediated manner; leading to proteasomal degradation. Ubiquitination by TRAF6 via 'Lys-27'-linked polyubiquitination and deubiquitination by USP38 serves as a critical regulatory mechanism for fine-tuning IL1RL1-mediated inflammatory response (PubMed:35238669).
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