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AB180301

Recombinant Human STAC protein (denatured) (His tag N-Terminus)

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Recombinant Human STAC protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 1 to 402 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

대체 명칭 보기

STAC1, STAC, SH3 and cysteine-rich domain-containing protein, Src homology 3 and cysteine-rich domain-containing protein

1 이미지
SDS-PAGE - Recombinant Human STAC protein (denatured) (His tag N-Terminus) (AB180301)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human STAC protein (denatured) (His tag N-Terminus) (AB180301)

15% SDS-PAGE analysis of ab180301 (3μg).

주요 정보

Purity

>85% SDS-PAGE

발현 시스템

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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보완 제품

Primary Antibodies

AB181157

Anti-STAC antibody [EPR12805] - N-terminal

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-STAC antibody [EPR12805] - N-terminal (AB181157)

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMIPPSSPREDGVDGLPKEAVGAEQPPSPASTSSQESKLQKLKRSLSFKTKSLRSKSADNFFQRTNSEDMKLQAHMVAEISPSSSPLPAPGSLTSTPARAGLHPGGKAHAFQEYIFKKPTFCDVCNHMIVGTNAKHGLRCKACKMSIHHKCTDGLAPQRCMGKLPKGFRRYYSSPLLIHEQFGCIKEVMPIACGNKVDPVYETLRFGTSLAQRTKKGSSGSGSDSPHRTSTSDLVEVPEEANGPGGGYDLRKRSNSVFTYPENGTDDFRDPAKNINHQGSLSKDPLQMNTYVALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRLQQNEKIFRCVRTFIGCKEQGQITLKENQICVSSEEEQDGFIRVLSGKKKGLIPLDVLENI","proteinLength":"Full Length","predictedMolecularWeight":"46.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":402,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q99469","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

STAC also known as SH3 and cysteine-rich domain 3 is a protein with a known molecular mass of approximately 38 kilodaltons. Structurally STAC contains a domain known as the SH3 domain which aids in protein-protein interactions. STAC expresses widely in various tissues including the brain heart and skeletal muscle. It interacts with other proteins through its cysteine-rich domain playing roles in cellular signaling.
Biological function summary

Proteins with SH3 domains like STAC contribute to intracellular signaling pathways. STAC interacts within complexes that modulate ion channel activities which is important for cellular excitability. It holds an essential role in synaptic transmission and muscle contraction functions. The presence of STAC in the membrane and cytosolic compartments suggests its involvement in dynamic cellular processes.

Pathways

STAC participates in both the calcium signaling pathway and the excitation-contraction coupling pathway. In calcium signaling it regulates calcium channels which are critical for maintaining cellular calcium homeostasis. Additionally STAC is involved with the excitation signal pathway by interacting with proteins such as RyR1 (Ryanodine Receptor 1) that facilitate calcium release in muscle contraction. This integration affects the overall physiological response during muscle excitation.

STAC shows an association with cardiac arrhythmias and muscular dystrophy. Mutations or altered expression in STAC can impact calcium homeostasis and muscle function contributing to these conditions. Additionally STAC links to the CACNA1S protein in muscular disorders associated with calcium channel dysfunction which further highlights its role in the pathophysiology of these diseases.
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일반 정보

기능

Promotes expression of the ion channel CACNA1H at the cell membrane, and thereby contributes to the regulation of channel activity. Plays a minor and redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C.

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제품 프로토콜

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타겟 정보

Promotes expression of the ion channel CACNA1H at the cell membrane, and thereby contributes to the regulation of channel activity. Plays a minor and redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C.
See full target information STAC
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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