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AB63280

Recombinant Human Stanniocalcin 1/STC protein

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(1 출판물)

Recombinant Human Stanniocalcin 1/STC protein is a Human Full Length protein, expressed in HEK 293 cells, with >95%, suitable for SDS-PAGE, ELISA, WB.
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SDS-PAGE - Recombinant Human Stanniocalcin 1/STC protein (AB63280)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Stanniocalcin 1/STC protein (AB63280)

LANE 1. M.W. marker - 14, 21, 31, 45, 66, 97 kDa. LANE 2. reduced and heated sample, 5µg/lane. LANE 3. non-reduced and non-heated sample, 5µg/lane

주요 정보

Purity

>95% SDS-PAGE

Please filter the product by an appropriate sterile filter before using it in the cell culture.

발현 시스템

HEK 293 cells

Tags

Tag free

Applications

SDS-PAGE, WB, ELISA

applications

Biologically active

No

Accession

P52823-1

Animal free

No

Carrier free

No

Species

Human

Reconstitution

Reconstitute at 0.5 mg/mL in water

보관 버퍼

Constituents: 0.242% Tris, 0.116% Sodium chloride

storage-buffer

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보완 제품

Reagents, Controls & Accessories

AB234617

Prestained Protein Ladder - Mid-range molecular weight (10 - 180 kDa)

SDS-PAGE - Prestained Protein Ladder - Mid-range molecular weight (10 - 180 kDa) (AB234617)

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Primary Antibodies

AB1187

HRP Anti-6X His tag® antibody

Western blot - HRP Anti-6X His tag® antibody (AB1187)

  • 4
  • 12
Primary Antibodies

AB248044

Anti-Stanniocalcin 1/STC antibody [EPR6055] - BSA and Azide free

RabMAb|Recombinant

Western blot - Anti-Stanniocalcin 1/STC antibody [EPR6055] - BSA and Azide free (AB248044)

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Assay Kits

AB213829

Human Stanniocalcin 1 / STC ELISA Kit (STC1)

Sandwich ELISA - Human Stanniocalcin 1 / STC ELISA Kit (STC1) (AB213829)

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Primary Antibodies

AB245114

Anti-6X His tag® antibody [JPAR-2]

20ul selling size|RabMAb|Recombinant|Lab Essentials

Flow Cytometry - Anti-6X His tag® antibody [JPAR-2] (AB245114)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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제품 세부 정보

Previously labelled as Stanniocalcin 1.
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서열 정보

[{"linker":null,"sequence":"THEAEQNDSV SPRKSRVAAQ NSAEVVRCLN SALQVGCGAF \r\nACLENSTCDT DGMYDICKSF LYSAAKFDTQ GKAFVKESLK \r\nCIANGVTSKV FLAIRRCSTF QRMIAEVQEE CYSKLNVCSI \r\nAKRNPEAITE VVQLPNHFSN RYYNRLVRSL LECDEDTVST \r\nIRDSLMEKIG PNMASLFHIL QTDHCAQTHP RADFNRRRTN \r\nEPQKLKVLLR NLRGEEDSPS HIKRTSHESA - ASDYKDDDDK","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":0,"aminoAcidStart":0,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"P52823","tags":[]}]
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특성 및 보관 정보

제형
Lyophilized
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
-80°C
적절한 장기 보관 조건
-80°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Stanniocalcin 1 (STC1) is a glycoprotein hormone with a mass of about 56 kDa. Alternate names for this protein include STC and STC-1. It is expressed in various tissues such as the kidney brain and ovary. STC1 plays a significant mechanical role in the regulation of calcium and phosphate transport across cell membranes. It interacts with certain receptors on cell surfaces to modulate ion exchange contributing to the maintenance of mineral homeostasis.
Biological function summary

Stanniocalcin 1 regulates calcium and phosphate balance and performs roles in cellular metabolism and antioxidant defense. It acts independently not as part of a complex but sometimes affects cascades leading to oxidative stress responses. STC1 adjusts energy metabolism by managing reactive oxygen species thereby enhancing cell survival under stress conditions. Its signaling impacts energy balance and adaptive responses in metabolically active tissues.

Pathways

Despite its independent operation Stanniocalcin 1 is integrated into oxidative stress and inflammatory pathways. It is involved in the Akt/PKB signaling pathway which influences cell survival and stress response. STC1 intersects with other proteins like PTH (parathyroid hormone) within the calcium metabolism pathways affecting bone and renal function. Through these pathways it facilitates cellular adaptation to metabolic demands.

Researchers link Stanniocalcin 1 to osteoporosis and cancer. Its role in calcium homeostasis makes it relevant in osteoporosis where bone density and strength are compromised. In the context of cancer STC1's influence on cell survival and stress responses may contribute to tumorigenesis although its function can be protective or detrimental depending on the cellular environment. The interaction of STC1 with proteins like PTH highlights its involvement in bone-related pathologies and potential roles in cancer progression.
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일반 정보

기능

Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.

서열 유사성

Belongs to the stanniocalcin family.

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제품 프로토콜

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타겟 정보

Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.
See full target information STC1

대체 명칭 보기

STC, STC1, Stanniocalcin-1, STC-1
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11:e2304123 PubMed38088577

2023

Stanniocalcin-1 Promotes PARP1-Dependent Cell Death via JNK Activation in Colitis.

Applications

Unspecified application

Species

Unspecified reactive species

Liguo Zhu,Zhuo Xie,Guang Yang,Gaoshi Zhou,Li Li,Shenghong Zhang
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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