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AB166097

Recombinant Human STEAP2 protein (GST tag N-Terminus)

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Recombinant Human STEAP2 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 490 aa range, expressed in Wheat germ, suitable for ELISA, WB.

대체 명칭 보기

PCANAP1, STAMP1, UNQ6507/PRO23203, STEAP2, Metalloreductase STEAP2, Prostate cancer-associated protein 1, Protein up-regulated in metastatic prostate cancer, Six-transmembrane epithelial antigen of prostate 2, SixTransMembrane protein of prostate 1, PUMPCn

1 이미지
SDS-PAGE - Recombinant Human STEAP2 protein (GST tag N-Terminus) (AB166097)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human STEAP2 protein (GST tag N-Terminus) (AB166097)

ab166097 on a 12.5% SDS-PAGE stained with Coomassie Blue.

주요 정보

발현 시스템

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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보완 제품

Reagents, Controls & Accessories

AB116028

Prestained Protein Ladder - Broad molecular weight (10 - 245 kDa)

SDS-PAGE - Prestained Protein Ladder - Broad molecular weight (10 - 245 kDa) (AB116028)

  • 5
  • 3
Reagents, Controls & Accessories

AB110413

Total OXPHOS Rodent WB Antibody Cocktail

Western blot - Total OXPHOS Rodent WB Antibody Cocktail (AB110413)

  • 5
  • 18
Assay Kits

AB65336

Triglyceride Assay Kit - Quantification

Biochemical assay - Triglyceride Assay Kit - Quantification (AB65336)

  • 4
  • 5
Proteins & Peptides

AB314537

Recombinant Macaca fascicularis Claudin18.2 protein - Active

Bioactive

Functional Studies - Recombinant Macaca fascicularis Claudin18.2 protein - Active (AB314537)

  • 0
  • 0
Primary Antibodies

AB134161

Anti-CD276 antibody [EPNCIR122]

RabMAb|Recombinant|KO Validated|20ul selling size

Western blot - Anti-CD276 antibody [EPNCIR122] (AB134161)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MESISMMGSPKSLSETFLPNGINGIKDARKVTVGVIGSGDFAKSLTIRLIRCGYHVVIGSRNPKFASEFFPHVVDVTHHEDALTKTNIIFVAIHREHYTSLWDLRHLLVGKILIDVSNNMRINQYPESNAEYLASLFPDSLIVKGFNVVSAWALQLGPKDASRQVYICSNNIQARQQVIELARQLNFIPIDLGSLSSAREIENLPLRLFTLWRGPVVVAISLATFFFLYSFVRDVIHPYARNQQSDFYKIPIEIVNKTLPIVAITLLSLVYLAGLLAAAYQLYYGTKYRRFPPWLETWLQCRKQLGLLSFFFAMVHVAYSLCLPMRRSERYLFLNMAYQQVHANIENSWNEEEVWRIEMYISFGIMSLGLLSLLAVTSIPSVSNALNWREFSFIQSTLGYVALLISTFHVLIYGWKRAFEEEYYRFYTPPNFVLALVLPSIVILGKIILFLPCISRKLKRIKKGWEKSQFLEEGMGGTIPHVSPERVTVM","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":490,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q8NFT2","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Proprietary technique
배송 시 보관 조건
Dry Ice
적절한 단기 보관 조건
-80°C
적절한 장기 보관 조건
-80°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

STEAP2 also known as six transmembrane epithelial antigen of the prostate 2 is a metalloreductase with a mass of about 56 kDa. It facilitates the reduction of metal ions in a process dependent on FAD and NADPH. Expressed mainly in the prostate STEAP2 also appears in other tissues at lower levels. This protein exhibits a tendency to localize to cellular membranes and endocytic vesicles aiding in the uptake and processing of metal ions like iron and copper which are important for cellular activities.
Biological function summary

STEAP2 plays a role in ion homeostasis and cellular proliferation. It acts as part of a complex involving other STEAP family members contributing to the reduction of metal ions essential for various cellular processes. Its ability to mediate electron transport is important for maintaining the balance of redox reactions critical for normal cellular functions. The involvement in cellular proliferation ties STEAP2 to tissue development and repair mechanisms.

Pathways

STEAP2 interacts within metal ion transport and homeostasis pathways influencing processes like oxidative stress responses. It associates with proteins such as ferritin important for iron storage and metallothioneins linked to metal detoxification. These interactions are essential for regulating intracellular metal ion concentrations thereby impacting cellular health and function. It also relates to cellular growth pathways connecting it to certain growth factor signals.

Abnormal STEAP2 expression links to prostate cancer and other proliferative disorders. Its overexpression in prostate cancer cells correlates with increased tumor aggressiveness and progression. STEAP2 interacts with other oncogenic proteins such as PSA (prostate-specific antigen) which are critical in the diagnosis and progression monitoring of prostate cancer. Additionally alterations in STEAP2 function may affect systemic metal ion homeostasis potentially contributing to disorders like hemochromatosis although this link is less well-defined in clinical settings.
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일반 정보

기능

Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane (By similarity). Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (By similarity). Can also reduce Cu(2+) to Cu(1+) (By similarity).

서열 유사성

Belongs to the STEAP family.

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제품 프로토콜

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타겟 정보

Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane (By similarity). Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (By similarity). Can also reduce Cu(2+) to Cu(1+) (By similarity).
See full target information STEAP2
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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