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AB202605

Recombinant Human Sulfite oxidase protein (His tag N-Terminus)

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Recombinant Human Sulfite oxidase protein (His tag N-Terminus) is a Human Full Length protein, in the 80 to 545 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

대체 명칭 보기

SUOX

1 이미지
SDS-PAGE - Recombinant Human Sulfite oxidase protein (His tag N-Terminus) (AB202605)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Sulfite oxidase protein (His tag N-Terminus) (AB202605)

15% SDS-PAGE using 3 μg of ab202605.

주요 정보

Purity

>90% SDS-PAGE

ab202605 was purified by using conventional chromatography techniques.

발현 시스템

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 7.4 Constituents: PBS, 30% Glycerol (glycerin, glycerine), 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

제품 세부 정보

Previously labelled as SUOX.

서열 정보

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMGSESTHIYTKEEVSSHTSPETGIWVTLGSEVFDVTEFVDLHPGGPSKLMLAAGGPLEPFWALYAVHNQSHVRELLAQYKIGELNPEDKVAPTVETSDPYADDPVRHPALKVNSQRPFNAEPPPELLTENYITPNPIFFTRNHLPVPNLDPDTYRLHVVGAPGGQSLSLSLDDLHNFPRYEITVTLQCAGNRRSEMTQVKEVKGLEWRTGAISTARWAGARLCDVLAQAGHQLCETEAHVCFEGLDSDPTGTAYGASIPLARAMDPEAEVLLAYEMNGQPLPRDHGFPVRVVVPGVVGARHVKWLGRVSVQPEESYSHWQRRDYKGFSPSVDWETVDFDSAPSIQELPVQSAITEPRDGETVESGEVTIKGYAWSGGGRAVIRVDVSLDGGLTWQVAKLDGEEQRPRKAWAWRLWQLKAPVPAGQKELNIVCKAVDDGYNVQPDTVAPIWNLRGVLSNAWHRVHVYVSP","proteinLength":"Full Length","predictedMolecularWeight":"53.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":545,"aminoAcidStart":80,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P51687","tags":[{"tag":"His","terminus":"N-Terminus"}]}]

특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Sulfite oxidase also known as SUOX has a molecular mass of approximately 57 kDa and plays a critical role in the conversion of sulfite to sulfate. This enzyme is located in the mitochondria of cells across various tissues but is prominently expressed in the liver and kidney. Its activity depends on molybdenum and heme cofactors rendering it an important player in cellular redox reactions.
Biological function summary

Sulfite oxidase acts in the detoxification process of sulfur-containing amino acids. It functions as a monomer and ensures that the potentially harmful intermediate sulfite is efficiently converted to the harmless end product sulfate which can then be excreted. This detoxification is important for cellular health and prevents accumulation of sulfite which could lead to oxidative damage.

Pathways

Sulfite oxidase plays an important part in two major metabolic processes: the sulfur amino acid detoxification pathway and the metabolic pathway of the degradation of branched-chain amino acids. It works together with cytochrome c in the electron transport chain to facilitate electron transfer. Sulfite oxidase’s function ensures proper catabolism of amino acids and assists in maintaining cellular homeostasis.

Sulfite oxidase deficiency can cause severe neurological impairment and developmental delay often linked to sulfite oxidase deficiency disorder itself. This genetic disorder results from mutations in the SUOX gene disrupting proper enzyme function. Associations have also been highlighted with neurological conditions where oxidative stress plays a part implicating this enzyme’s failure to properly regulate sulfite levels. Additionally its interactions with the molybdenum cofactor highlight connections to molybdenum cofactor deficiency further illustrating its importance in human health.

일반 정보

기능

Catalyzes the oxidation of sulfite to sulfate, the terminal reaction in the oxidative degradation of sulfur-containing amino acids.

Subcellular localisation

Mitochondrion intermembrane space

제품 프로토콜

타겟 정보

Catalyzes the oxidation of sulfite to sulfate, the terminal reaction in the oxidative degradation of sulfur-containing amino acids.
See full target information SUOX

Product promise

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