Recombinant human TAF1L protein (GST tag N-Terminus)

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Biological function summary

The function of TAF1L involves acting as a cofactor in RNA polymerase II transcription. TAF1L is part of the TFIID complex which also includes TBP and several other TAFs. This complex assists in the recognition of the core promoter sequences and is essential in the formation of the transcription preinitiation complex. Beyond general transcription tasks TAF1L modifies chromatin structure to facilitate the binding of other transcription machinery and potentially influences gene expression patterns specific to certain tissues.

Pathways

TAF1L interacts with components critical to the transcription machinery. It operates within the RNA polymerase II transcription initiation pathway aligning with other TAFs and TBP to recruit RNA polymerase II to the promoter regions of target genes. Furthermore TAF1L plays roles in pathways influencing chromatin remodeling interacting with histone modifying proteins to aid in transcription regulation. Both these pathways highlight the importance of TAF1L in regulating gene expression.