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AB140046

Recombinant Human TANK/TRAF2 protein (His tag N-Terminus)

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Recombinant Human TANK/TRAF2 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 448 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

대체 명칭 보기

ITRAF, TRAF2, TANK, TRAF family member-associated NF-kappa-B activator, TRAF-interacting protein, I-TRAF

1 이미지
SDS-PAGE - Recombinant Human TANK/TRAF2 protein (His tag N-Terminus) (AB140046)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human TANK/TRAF2 protein (His tag N-Terminus) (AB140046)

15% SDS-PAGE analysis of ab140046 (3μg).

주요 정보

Purity

>85% SDS-PAGE

ab140046 was purified by using conventional chromatography techniques.

발현 시스템

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 8 Constituents: 50% Glycerol (glycerin, glycerine), 1.17% Sodium chloride, 0.32% Tris HCl, 0.03% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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보완 제품

Reagents, Controls & Accessories

AB313996

Prestained Protein Ladder - Extra broad molecular weight (3 - 260 kDa)

SDS-PAGE - Prestained Protein Ladder - Extra broad molecular weight (3 - 260 kDa) (AB313996)

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Proteins & Peptides

AB204091

Recombinant Human TRAF2 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human TRAF2 protein (AB204091)

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  • 0
Proteins & Peptides

AB60879

Recombinant human RIP2 protein (GST tag N-Terminus)

Functional Studies - Recombinant human RIP2 protein (AB60879)

  • 0
  • 0
Proteins & Peptides

AB271732

Recombinant human RIP protein (Active) (GST tag N-Terminus)

Functional Studies - Recombinant human RIP protein (Active) (GST tag N-Terminus) (AB271732)

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  • 0
Proteins & Peptides

AB114410

Recombinant Human cIAP1 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human cIAP1 protein (GST tag N-Terminus) (AB114410)

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  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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제품 세부 정보

This product was previously labelled as TANK
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서열 정보

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKTENYEQRIREQQEQLSLQQTIIDKLKSQLLLVNSTQDNNYGCVPLLEDSETRKNNLTLDQPQDKVISGIAREKLPKVRRQEVSSPRKETSARSLGSPLLHERGNIEKTFWDLKEEFHKICMLAKAQKDHLSKLNIPDTATETQCSVPIQCTDKTDKQEALFKPQAKDDINRGAPSITSVTPRGLCRDEEDTSFESLSKFNVKFPPMDNDSTFLHSTPERPGILSPATSEAVCQEKFNMEFRDNPGNFVKTEETLFEIQGIDPIASAIQNLKTTDKTKPSNLVNTCIRTTLDRAACLPPGDHNALYVNSFPLLDPSDAPFPSLDSPGKAIRGPQQPIWKPFPNQDSDSVVLSGTDSELHIPRVCEFCQAVFPPSITSRGDFLRHLNSHFNGET","proteinLength":"Full Length","predictedMolecularWeight":"50.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":448,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q92844","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
-20°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

TANK (TRAF family member-associated NF-kappa-B activator) and TRAF2 (TNF receptor-associated factor 2) are proteins involved in the regulation of immune responses. TANK also known as I-TRAF is a protein with a mass of approximately 49 kDa. TRAF2 has a mass of approximately 56 kDa. These proteins express in various immune cells including T and B lymphocytes. TANK interacts with TRAF2 to mediate downstream signaling pathways essential for immunity.
Biological function summary

The TANK/TRAF2 complex plays a role in modulating the NF-kappa-B signaling pathway which is important for inflammation and immune responses. This complex also contributes to cellular responses to stress and infection. TANK acts as an adaptor protein that interacts with TRAF2 to relay signals from upstream receptors ensuring proper immune function. Additionally TANK inhibits excessive activation of NF-kappa-B maintaining a balanced immune response.

Pathways

As it relates to regulating immune functions TANK/TRAF2 is pivotal in the NF-kappa-B and MAPK signaling pathways. In the NF-kappa-B pathway TRAF2 helps mediate the activation of downstream kinases which are critical for the translocation of NF-kappa-B to the nucleus. TANK works alongside other signaling molecules like TRAF3 and TRAF6 integrating signals that lead to gene transcription involved in immune response and cell survival.

The dysfunction of TANK/TRAF2 differs from normal regulatory controls it links to auto-inflammatory diseases and certain cancers. In autoimmune disorders such as systemic lupus erythematosus aberrant NF-kappa-B activity possibly influenced by TANK/TRAF2 leads to uncontrolled immune activation. In cancer particularly lymphomas altered TANK/TRAF2 signaling correlates with the unchecked proliferation of cells. The protein's interplay with receptor-interacting protein 1 (RIP1) further emphasizes its role as disruptions in this interaction are seen in pathological states.
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일반 정보

기능

Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed : 25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed : 25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed : 25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2.

Post-translational modifications

Phosphorylated by IKBKE.. (Microbial infection) Cleaved by encephalomyocarditis virus (EMCV) protease 3C (PubMed:26363073). This cleavage allows the virus to disrupt the TANK-TBK1-IKKepsilon-IRF3 complex, thereby inhibiting the induction of the IFN-beta signal pathway (PubMed:28487378).. (Microbial infection) Cleaved by Seneca Valley virus protease 3C allowing the virus to suppress interferon type-I through both RIG-I and Toll-like receptor-dependent pathways.

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제품 프로토콜

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타겟 정보

Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed : 25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed : 25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed : 25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2.
See full target information TANK
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Product promise

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