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AB152750

Recombinant Human TLE4 protein (GST tag N-Terminus)

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Recombinant Human TLE4 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 773 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

대체 명칭 보기

GRG4, KIAA1261, TLE4, Transducin-like enhancer protein 4, Grg-4, Groucho-related protein 4

1 이미지
SDS-PAGE - Recombinant Human TLE4 protein (GST tag N-Terminus) (AB152750)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human TLE4 protein (GST tag N-Terminus) (AB152750)

12.5% SDS-PAGE analysis of ab152750 stained with Coomassie Blue.

주요 정보

발현 시스템

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB, SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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보완 제품

Primary Antibodies

AB64833

Anti-TLE4 antibody

Western blot - Anti-TLE4 antibody (AB64833)

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MIRDLSKMYPQTRHPAPHQPAQPFKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNAICAQVIPFLSQEHQQQVVQAVERAKQVTMAELNAIIGQQLQAQHLSHGHGLPVPLTPHPSGLQPPAIPPIGSSAGLLALSSALGGQSHLPIKDEKKHHDNDHQRDRDSIKSSSVSPSASFRGAEKHRNSADYSSESKKQKTEEKEIAARYDSDGEKSDDNLVVDVSNEDPSSPRGSPAHSPRENGLDKTRLLKKDAPISPASIASSSSTPSSKSKELSLNEKSTTPVSKSNTPTPRTDAPTPGSNSTPGLRPVPGKPPGVDPLASSLRTPMAVPCPYPTPFGIVPHAGMNGELTSPGAAYAGLHNISPQMSAAAAAAAAAAAYGRSPVVGFDPHHHMRVPAIPPNLTGIPGGKPAYSFHVSADGQMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMENSNVEVLHVTKPDKYQLHLHESCVLSLKFAHCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEVIY","proteinLength":"Full Length","predictedMolecularWeight":"110.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":773,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q04727","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Proprietary technique
배송 시 보관 조건
Dry Ice
적절한 단기 보관 조건
-80°C
적절한 장기 보관 조건
-80°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Transducin-like enhancer of split 4 (TLE4) is a transcriptional corepressor involved in the regulation of gene expression. It is also known as ESG (Enhancer of split groucho) or GRG4. TLE4 belongs to the Groucho/TLE protein family which shares a general structure characterized by WD40 repeats. The protein has a molecular mass of about 82 kDa. TLE4 expresses in several tissues including the brain heart and peripheral blood leukocytes indicating its broad functional importance.
Biological function summary

TLE4 participates in the repression of transcription by forming a multiprotein complex. It acts as a corepressor that interacts with various transcription factors often modulating the expression of genes involved in developmental processes. TLE4 commonly partners with transcription factors from the basic helix-loop-helix (bHLH) family which play a significant role in the regulation of neuronal and muscular development. The repression activity of TLE4 makes it a temporal regulator helping maintain and coordinate gene expression during cellular differentiation.

Pathways

TLE4 functions within the Wnt signaling and Notch signaling pathways. Both of these pathways are important for cell fate determination and organ development. In the Wnt pathway TLE4 interacts with beta-catenin to modulate transcriptional activity contributing to cellular responses to external signals. In the Notch signaling pathway TLE4 associates with core transcription factors like CSL (CBF1/Suppressor of Hairless/Lag1) to regulate the expression of Notch target genes facilitating diverse developmental processes.

TLE4 has links to hematological malignancies and neurological conditions. Its dysregulation can contribute to conditions like acute myeloid leukemia (AML) alongside proteins such as RUNX1 which play a role in hematopoiesis and myeloid lineage development. Additionally altered TLE4 expression has associations with neurodevelopmental disorders as its interaction with key proteins in neuronal differentiation is disturbed affecting neuronal function and development.
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일반 정보

기능

Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity). Involved in transcriptional repression of GNRHR and enhances MSX1-mediated transcriptional repression of CGA/alpha-GSU (By similarity).

서열 유사성

Belongs to the WD repeat Groucho/TLE family.

Post-translational modifications

Phosphorylated. PAX5 binding increases phosphorylation.. Ubiquitinated by XIAP/BIRC4.

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제품 프로토콜

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타겟 정보

Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity). Involved in transcriptional repression of GNRHR and enhances MSX1-mediated transcriptional repression of CGA/alpha-GSU (By similarity).
See full target information TLE4
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Product promise

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