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AB314627

Recombinant Human TMEM72 Protein (His Tag)

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Recombinant Human TMEM72 Protein (His Tag) is a Human Full Length protein, in the 1 to 275 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

대체 명칭 보기

C10orf127, KSP37, TMEM72, Transmembrane protein 72, Kidney-specific secretory protein of 37 kDa

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SDS-PAGE - Recombinant Human TMEM72 Protein (His Tag) (AB314627)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human TMEM72 Protein (His Tag) (AB314627)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel. The difference between the theoretical value and the observed value may be related to the molecular structure of the protein. It is predicted that the isoelectric point pI of the fusion protein is 5.39, the acidic protein usually shows higher molecular weight when runs on the gel. There is also evidence of alternative splicing of the protein, and alternative splicing can produce proteins of different sizes from the same gene. It is speculated that the protein forms a dimeric structure. Observed band size : Monomer：40 kDa Dimer：80 kDa

주요 정보

Purity

>85% SDS-PAGE

발현 시스템

Escherichia coli

Tags

10x His tag N-Terminus Myc tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

Yes

Carrier free

No

Species

Human

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%.

보관 버퍼

pH: 7.4 - 8 Constituents: 6% Trehalose, 0.87% Sodium chloride, 0.24% Tris, 0.05% 2-Octadecoxyethanol

storage-buffer

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보완 제품

Primary Antibodies

AB122598

Anti-TMEM72 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TMEM72 antibody (AB122598)

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MQLQVFWTGLEYTCRLLGITTAAVLIGVGTETFLQGQFKSLAFYLLFTGAAVSICEGAYFVAQLLAICFQCQPGSLADRVREKAHWLGCFQKFLAYLLLSVACFLHPVLVWHVTIPGSMLIITGLAYFLLSKRKKRKAAPEVLASPEQYTDPSSSAVSTTGSGDTEQTYTFHGALKEGPSSLFIHMKSILKGTKKPSALQPPNTLMELSLEPADSLAKKKQVHFEDNLVRIVPSLAEGLDDGDSEPEETTSDTTPIIPPPQAPLFLSSLTATGLF","proteinLength":"Full Length","predictedMolecularWeight":"36.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":275,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"A0PK05","tags":[{"tag":"10x His","terminus":"N-Terminus"},{"tag":"Myc","terminus":"C-Terminus"}]}]
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특성 및 보관 정보

제형
Lyophilized
Purification 테크닉
Ion exchange chromatography
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-80°C
분주 정보
Add glycerol to a final volume of 50% for extra stability and aliquot
보관 정보
The product can be stored for up to 12 months
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

TMEM72 also known as Transmembrane Protein 72 is a transmembrane protein with a mass of approximately 23 kDa. TMEM72 exhibits expression in various tissues including the kidney and liver. It primarily locates in the membrane structure where it participates in cellular transport processes. The protein possesses domains that facilitate interactions with other cellular components contributing to its mechanical functions.
Biological function summary

TMEM72 involves itself in cellular homeostasis and regulatory processes. It operates as part of cellular transport systems influencing ion balance within cells. TMEM72 does not function alone and is part of the larger complex of proteins that regulate membrane permeability. Its activity impacts how cells respond to environmental changes which affects the overall functioning of organ systems where it is expressed.

Pathways

Researchers link TMEM72 to significant cellular pathways such as ion transport and homeostasis. In these pathways it interacts with other proteins including ion channel proteins to manage ion flow across membranes. TMEM72 plays a role in maintaining the electrochemical gradients necessary for cell survival and proper function positioning it as an important component in both the physiological and pathophysiological contexts.

TMEM72 may relate to conditions affecting ion balance and membrane transport. Abnormalities in this protein's function can be observed in certain kidney diseases where ion transport is disrupted. Additionally TMEM72 might have connections to liver disorders in which impaired regulation of ion flow exacerbates disease progression. Proteins such as ion channels associate with these diseases with TMEM72 acting as an important to understanding and potentially targeting these disorders for therapeutic interventions.
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일반 정보

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제품 프로토콜

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타겟 정보

See full target information TMEM72
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Product promise

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