Recombinant Human TNF Receptor II protein (Fc tag C-Term + His tag C-Term + Avi tag C-Term)
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Recombinant Human TNF Receptor II protein (Fc tag C-Term + His tag C-Term + Avi tag C-Term) is a Human Fragment protein, in the 23 to 257 aa range, expressed in HEK 293 cells, with >90%, suitable for SDS-PAGE.
대체 명칭 보기
CD120b, TNFBR, TNFR2, TNFRSF1B, Tumor necrosis factor receptor superfamily member 1B, Tumor necrosis factor receptor 2, Tumor necrosis factor receptor type II, p75, p80 TNF-alpha receptor, TNF-R2, TNF-RII, TNFR-II
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human TNF Receptor II protein (Fc tag C-Term + His tag C-Term + Avi tag C-Term) (AB271768)
SDS-PAGE analysis of 4 μg ab271768.
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특성 및 보관 정보
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보관 정보
일반 정보
기능
Receptor with high affinity for TNFSF2/TNF and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF. Isoform 2 blocks TNF-induced apoptosis, which suggests that it regulates TNF function by antagonizing its biological activity.
Post-translational modifications
Phosphorylated; mainly on serine residues and with a very low level on threonine residues.. A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing.
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