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AB186079

Recombinant Human TRIB1 protein (GST tag N-Terminus)

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Recombinant Human TRIB1 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 372 aa range, expressed in Baculovirus infected Sf9 cells, with >95%, suitable for SDS-PAGE, WB.
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SDS-PAGE - Recombinant Human TRIB1 protein (GST tag N-Terminus) (AB186079)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human TRIB1 protein (GST tag N-Terminus) (AB186079)

SDS-PAGE of ab186079.

주요 정보

Purity

>95% SDS-PAGE

Affinity purified.

발현 시스템

Baculovirus infected Sf9 cells

Tags

GST tag N-Terminus

Applications

SDS-PAGE, WB

applications

Biologically active

No

Accession

Q96RU8-1

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 7.5 Constituents: 25% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.79% Tris HCl, 0.31% Glutathione, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF

storage-buffer

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보완 제품

Reagents, Controls & Accessories

AB313996

Prestained Protein Ladder - Extra broad molecular weight (3 - 260 kDa)

SDS-PAGE - Prestained Protein Ladder - Extra broad molecular weight (3 - 260 kDa) (AB313996)

  • 0
  • 0
Assay Kits

AB126459

STAT3 (pY705) + total STAT3 ELISA Kit

Sandwich ELISA - STAT3 (pY705) + total STAT3 ELISA Kit (AB126459)

  • 0
  • 0
Primary Antibodies

AB33907

Anti-Rel B antibody [EP614Y]

RabMAb|Recombinant|KO Validated

Flow Cytometry (Intracellular) - Anti-Rel B antibody [EP614Y] (AB33907)

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Proteins & Peptides

AB164895

Recombinant Human Protocadherin 21 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human Protocadherin 21 protein (GST tag N-Terminus) (AB164895)

  • 0
  • 0
Assay Kits

AB264629

Human STAT3 ELISA Kit

Recombinant|SimpleStep

ELISA - Human STAT3 ELISA Kit (AB264629)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MRVGPVRSAMSGASQPRGPALLFPATRGVPAKRLLDADDAAAVAAKCPRLSECSSPPDYLSPPGSPCSPQPPPAAPGAGGGSGSAPGPSRIADYLLLPLAEREHVSRALCIHTGRELRCKVFPIKHYQDKIRPYIQLPSHSNITGIVEVILGETKAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERLTAPEILLHPWFESVLEPGYIDSEIGTSDQIVPEYQEDSDISSFFC","proteinLength":"Full Length","predictedMolecularWeight":"70 kDa","actualMolecularWeight":null,"aminoAcidEnd":372,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Baculovirus infected Sf9 cells","accessionNumber":"Q96RU8","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification
배송 시 보관 조건
Dry Ice
적절한 단기 보관 조건
-80°C
적절한 장기 보관 조건
-80°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

TRIB1 also known as tribbles homolog 1 is a pseudo kinase protein with a mass of approximately 41 kDa. It lacks catalytic activity typically expected from kinases but it plays a critical mechanical role via its protein interactions. TRIB1 is expressed in various human tissues including liver spleen and heart. It acts mainly through modulating protein degradation and transcription regulation processes.
Biological function summary

TRIB1 impacts cell signaling and metabolic processes by forming complexes with other proteins. It exerts a regulatory role by binding to E3 ubiquitin ligases influencing the degradation of target proteins. TRIB1 also interacts with transcription factors affecting gene expression. These actions highlight its involvement in maintaining cellular homeostasis by controlling inflammatory responses and metabolic pathways.

Pathways

TRIB1 influences metabolic and signaling pathways by interacting with key regulatory proteins. It plays a significant role within the MAP kinase pathway and the PI3K-AKT pathway. Both pathways are important for cell proliferation survival and metabolism. In these pathways proteins like ATF4 in the MAP kinase pathway and AKT1 in the PI3K-AKT pathway associate with TRIB1 allowing it to exert control over important cellular processes.

TRIB1 is linked to conditions such as cardiovascular disease and certain cancers. Its regulatory function within metabolic pathways connects it to lipid metabolism disorders impacting cardiovascular health. TRIB1 also relates to leukemia through its interactions with the transcription factor C/EBPα. Dysregulation of TRIB1 expression or function can disrupt normal cellular functions leading to disease progression.
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제품 프로토콜

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타겟 정보

Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase (PubMed : 27041596). The COP1-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed : 26455797). Serves to alter COP1 substrate specificity by directing the activity of COP1 toward CEBPA (PubMed : 27041596). Binds selectively the recognition sequence of CEBPA (PubMed : 26455797). Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner (By similarity). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity). Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (PubMed : 15299019, PubMed : 26455797).
See full target information TRIB1

대체 명칭 보기

C8FW, GIG2, TRB1, TRIB1, Tribbles homolog 1, TRB-1, G-protein-coupled receptor-induced gene 2 protein, SKIP1, GIG-2
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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