Recombinant Human TSG6 protein (His tag) is a Human Full Length protein, in the 18 to 277 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.
대체 명칭 보기
TSG6, TNFAIP6, Tumor necrosis factor-inducible gene 6 protein, Hyaluronate-binding protein, TNF-stimulated gene 6 protein, Tumor necrosis factor alpha-induced protein 6, TSG-6, TNF alpha-induced protein 6
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human TSG6 protein (His tag) (AB236337)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) analysis with 5% enrichment gel and 15% separation gel of ab236337.
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Primary Antibodies
AB267469
Anti-TSG6 antibody [EPR17582-45]
RabMAb|Recombinant|20ul selling size
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This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
TSG6 contributes to the modulation of the inflammatory response and tissue remodeling. It does this by interacting with molecules such as hyaluronan which is an important component of the extracellular matrix. During inflammatory responses TSG6 forms a complex with inter-α-inhibitor a serine protease inhibitor enhancing its stability and function. Through these interactions TSG6 helps to regulate the extracellular environment during tissue repair processes.
Pathways
The protein TSG6 participates actively in the inflammatory pathway and the hyaluronan metabolism pathway. It influences inflammatory events by modulating the activity of inflammatory cytokines affecting processes like leukocyte recruitment. TSG6 works closely with proteins such as TNF-α and IL-1 both integral to the inflammatory response. In the hyaluronan pathway TSG6 influences the structural organization of the matrix affecting cell migration and adhesion.
일반 정보
기능
Major regulator of extracellular matrix organization during tissue remodeling (PubMed : 15917224, PubMed : 18042364, PubMed : 26823460). Catalyzes the transfer of a heavy chain (HC) from inter-alpha-inhibitor (I-alpha-I) complex to hyaluronan. Cleaves the ester bond between the C-terminus of the HC and GalNAc residue of the chondroitin sulfate chain in I-alpha-I complex followed by transesterification of the HC to hyaluronan. In the process, potentiates the antiprotease function of I-alpha-I complex through release of free bikunin (PubMed : 15917224, PubMed : 16873769, PubMed : 20463016). Acts as a catalyst in the formation of hyaluronan-HC oligomers and hyaluronan-rich matrix surrounding the cumulus cell-oocyte complex, a necessary step for oocyte fertilization (PubMed : 26468290). Assembles hyaluronan in pericellular matrices that serve as platforms for receptor clustering and signaling. Enables binding of hyaluronan deposited on the surface of macrophages to LYVE1 on lymphatic endothelium and facilitates macrophage extravasation. Alters hyaluronan binding to functionally latent CD44 on vascular endothelium, switching CD44 into an active state that supports leukocyte rolling (PubMed : 15060082, PubMed : 26823460). Modulates the interaction of chemokines with extracellular matrix components and proteoglycans on endothelial cell surface, likely preventing chemokine gradient formation (PubMed : 27044744). In a negative feedback mechanism, may limit excessive neutrophil recruitment at inflammatory sites by antagonizing the association of CXCL8 with glycosaminoglycans on vascular endothelium (PubMed : 24501198). Has a role in osteogenesis and bone remodeling. Inhibits BMP2-dependent differentiation of mesenchymal stem cell to osteoblasts (PubMed : 16771708, PubMed : 18586671). Protects against bone erosion during inflammation by inhibiting TNFSF11/RANKL-dependent osteoclast activation (PubMed : 18586671).
Post-translational modifications
N-glycosylated.
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