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AB131704

Recombinant Human TULP1 protein (His tag N-Terminus)

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Recombinant Human TULP1 protein (His tag N-Terminus) is a Human Fragment protein, in the 290 to 542 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

대체 명칭 보기

TUBL1, TULP1, Tubby-related protein 1, Tubby-like protein 1

1 이미지
SDS-PAGE - Recombinant Human TULP1 protein (His tag N-Terminus) (AB131704)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human TULP1 protein (His tag N-Terminus) (AB131704)

15% SDS-PAGE showing ab131704 at approximately 31.1 kDa (3µg).

주요 정보

Purity

>90% SDS-PAGE

ab131704 is purified using conventional chromatography techniques

발현 시스템

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 8 Constituents: 50% Glycerol (glycerin, glycerine), 1.17% Sodium chloride, 0.32% Tris HCl, 0.08% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.06% EDTA

storage-buffer

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보완 제품

Reagents, Controls & Accessories

AB325997

Prestained Protein Ladder - Extra broad molecular weight (3-250 kDa, 5-color)

SDS-PAGE - Prestained Protein Ladder - Extra broad molecular weight (3-250 kDa, 5-color) (AB325997)

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  • 0
Assay Kits

AB245880

H&E Staining Kit (Hematoxylin and Eosin)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - H&E Staining Kit (Hematoxylin and Eosin) (AB245880)

  • 5
  • 3
Proteins & Peptides

AB241527

Recombinant Human Nucleolin protein (His tag)

Mass Spectrometry - Recombinant Human Nucleolin protein (His tag) (AB241527)

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  • 0
Proteins & Peptides

AB128431

Recombinant Human Thymidine Kinase 1/TK1 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human Thymidine Kinase 1/TK1 protein (His tag N-Terminus) (AB128431)

  • 0
  • 0
Assay Kits

AB150662

Alcian Blue Stain Kit (pH 2.5, Mucin Stain)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Alcian Blue Stain Kit (pH 2.5, Mucin Stain) (AB150662)

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  • 1
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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서열 정보

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMGSEPREFVLRPAPQGRTVRCRLTRDKKGMDRGMYPSYFLHLDTEKKVFLLAGRKRKRSKTANYLISIDPTNLSRGGENFIGKLRSNLLGNRFTVFDNGQNPQRGYSTNVASLRQELAAVIYETNVLGFRGPRRMTVIIPGMSAENERVPIRPRNASDGLLVRWQNKTLESLIELHNKPPVWNDDSGSYTLNFQGRVTQASVKNFQIVHADDPDYIVLQFGRVAEDAFTLDYRYPLCALQAFAIALSSFDGKLACE","proteinLength":"Fragment","predictedMolecularWeight":"31.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":542,"aminoAcidStart":290,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O00294","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The TULP1 protein also known as TUB-like protein 1 is a 64 kDa protein primarily expressed in retinal tissue. This protein has a significant role in intracellular trafficking pathways. Mechanically TULP1 interacts with other proteins to ensure the proper transport of photoreceptor-specific cargo. This interaction contributes to maintaining cellular function by keeping the photoreceptor cells healthy.
Biological function summary

TULP1 is critical for the photoreceptor cells' viability and functionality. It does not operate as a solitary entity but rather as a part of a larger molecular complex involved in managing the phototransduction pathways. By partnering with various molecules TULP1 mediates the movement and turnover of phototransduction components helping to maintain the cell structure and promote vision stability.

Pathways

TULP1 plays a significant role in the phototransduction and retinoid cycle pathways. Within these pathways TULP1 collaborates with essential proteins like RPGR and rhodopsin. These collaborations help regulate the transport processes necessary for photoreceptor cell homeostasis contributing to normal visual function and preservation of the retina's structural integrity.

TULP1 mutations associate with retinal-related conditions like retinitis pigmentosa and Leber congenital amaurosis. The connection between TULP1 and these disorders stems from disrupted function of TULP1 leading to impaired transport and eventual photoreceptor degeneration. Additionally a lack of functional interaction between TULP1 and other proteins like rhodopsin contributes significantly to retinal cell damage highlighting TULP1's relevance in hereditary retinal diseases.
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일반 정보

기능

Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long-term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein transport in photoreceptor cells (By similarity). Binds lipids, especially phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-bisphosphate, phosphatidylserine and phosphatidic acid (in vitro). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages.

서열 유사성

Belongs to the TUB family.

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제품 프로토콜

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타겟 정보

Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long-term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein transport in photoreceptor cells (By similarity). Binds lipids, especially phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-bisphosphate, phosphatidylserine and phosphatidic acid (in vitro). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages.
See full target information TULP1
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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