Recombinant Human TUSC2/FUS1 protein (GST tag N-Terminus)

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The TUSC2/FUS1 protein also known by its alternate name TUSC2 plays an essential role in cellular processes. It has a molecular mass of approximately 12 kDa and is found throughout various tissues but is predominantly expressed in the mitochondria. TUSC2 localizes to chromosomal region 3p21.3 which often undergoes deletions in lung cancer. Its expression can be lost or significantly reduced in certain cancers indicating its potential tumor-suppressive role.

Biological function summary

TUSC2 participates in several critical cellular functions and is part of a larger complex with other proteins. It influences cell proliferation apoptosis and signal transduction pathways. TUSC2 functions as a tumor suppressor helping to regulate cell growth and prevent malignant transformation. It acts in apoptosis induction and cell cycle control often by modulating reactive oxygen species (ROS) levels within cells.

Pathways

TUSC2 is instrumental in regulating several cellular pathways. It is a participant in the PI3K/Akt and MAPK pathways which are vital for cell survival growth and metabolism. TUSC2 interacts with proteins like Akt and p53 playing an important role in maintaining cellular homeostasis and preventing aberrant cell division. These interactions help TUSC2 modulate apoptosis and promote cell-cycle arrest under stressful conditions.

TUSC2 has a notable connection to cancer particularly lung cancer and mesothelioma. In these diseases TUSC2 expression often decreases due to chromosomal deletions. The protein's interaction with other tumor suppressors such as p53 and PTEN influences tumorigenesis by disrupting normal signaling pathways leading to uncontrolled cell proliferation. Restoring TUSC2 function or expression could open avenues for therapeutic interventions in cancer treatment.