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AB271782

Recombinant Human ULBP1 protein (Fc tag C-Terminus + Avi tag C-Terminus)

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Recombinant Human ULBP1 protein (Fc tag C-Terminus + Avi tag C-Terminus) is a Human Fragment protein, in the 26 to 215 aa range, expressed in Baculovirus infected Sf9 cells, with >90%, suitable for SDS-PAGE.

대체 명칭 보기

N2DL1, RAET1I, ULBP1, UL16-binding protein 1, ALCAN-beta, NKG2D ligand 1, Retinoic acid early transcript 1I, N2DL-1, NKG2DL1

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SDS-PAGE - Recombinant Human ULBP1 protein (Fc tag C-Terminus + Avi tag C-Terminus) (AB271782)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human ULBP1 protein (Fc tag C-Terminus + Avi tag C-Terminus) (AB271782)

SDS-PAGE analysis of ab271782.

주요 정보

Purity

>90% SDS-PAGE

Affinity purified.

발현 시스템

Baculovirus infected Sf9 cells

Tags

Fc tag C-Terminus Avi tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Animal free

No

Carrier free

No

Species

Human

보관 버퍼

pH: 7.4 Constituents: 20% Glycerol (glycerin, glycerine), 0.64% Sodium chloride, 0.13% Sodium phosphate, 0.02% Potassium chloride

storage-buffer

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보완 제품

Proteins & Peptides

AB128443

Recombinant Human ULBP2 protein (denatured) (His tag N-Terminus)

SDS-PAGE - Recombinant Human ULBP2 protein (denatured) (His tag N-Terminus) (AB128443)

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Proteins & Peptides

AB313356

Recombinant Human IDO1 Protein (His tag) (E.Coli)

Mass Spectrometry - Recombinant Human IDO1 Protein (His tag) (E.Coli) (AB313356)

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  • 0
Primary Antibodies

AB311847

Anti-Indoleamine 2, 3-dioxygenase antibody [EPR28349-89]

BOND RX™ Validated|20ul selling size|KO Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Indoleamine 2, 3-dioxygenase antibody [EPR28349-89] (AB311847)

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Primary Antibodies

AB62540

Anti-MICA antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MICA antibody (AB62540)

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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제품 세부 정보

Enzymatically biotin-labeled using Avi-tag™ technology
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서열 정보

[{"linker":null,"sequence":"GWVDTHCLCYDFIITPKSRPEPQWCEVQGLVDERPFLHYDCVNHKAKAFASLGKKVNVTKTWEEQTETLRDVVDFLKGQLLDIQVENLIPIEPLTLQARMSCEHEAHGHGRGSWQFLFNGQKFLLFDSNNRKWTALHPGAKKMTEKWEKNRDVTMFFQKISLGDCKMWLEEFLMYWEQMLDPTKPPSLAP","proteinLength":"Fragment","predictedMolecularWeight":"51 kDa","actualMolecularWeight":null,"aminoAcidEnd":215,"aminoAcidStart":26,"nature":"Recombinant","expressionSystem":"Baculovirus infected Sf9 cells","accessionNumber":"Q9BZM6","tags":[{"tag":"Fc","terminus":"C-Terminus"},{"tag":"Avi","terminus":"C-Terminus"}]}]
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification
배송 시 보관 조건
Dry Ice
적절한 단기 보관 조건
-80°C
적절한 장기 보관 조건
-80°C
보관 정보
Avoid freeze / thaw cycle
False
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

ULBP1 also known as UL16-binding protein 1 is a member of the MHC class I-related molecules. It weighs approximately 28 kDa. ULBP1 acts mechanically as a ligand for the NKG2D receptor part of the activating receptor on natural killer (NK) cells and certain T cells. It is primarily expressed on the surface of various cells including epithelial and some tumor cells. Its expression can be induced by cellular stress or infection.
Biological function summary

This protein plays a critical role in immune surveillance and response to malignancies and infections. ULBP1 does not form a complex on its own but it works closely with other NKG2D ligands contributing to the immune system's ability to recognize and eliminate abnormal cells. Its presence can enhance immune cell-mediated cytotoxicity indicating its role in immune defense.

Pathways

The protein takes an active part in the immune system activation interacting notably within the NK cell-mediated cytotoxicity pathway. It functions alongside other NKG2D ligands like MICA/MICB to modulate the activity of NK cells and T cells. This connection to the NKG2D pathway ensures a critical interface between innate and adaptive immunity reinforcing defense against infected or tumor cells.

Researchers have noted associations between ULBP1 and cancer progression or immune evasion. Its upregulation on tumor cells can lead to tumor clearance; however some cancers may shed ULBP1 to escape immune detection. In autoimmune diseases such as rheumatoid arthritis altered expression of ULBP1 and its interaction with NKG2D can potentially exacerbate inflammation. These interactions emphasize the balance that ULBP1 maintains in managing immune responses and its implications in pathology.
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일반 정보

기능

Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.

서열 유사성

Belongs to the MHC class I family.

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제품 프로토콜

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타겟 정보

Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
See full target information ULBP1
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Product promise

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